When DNA is replicated it is vulnerable to decay; the ability of cells to deal with this stress is a major factor in protecting our genomes from instability and cancer. A key mechanism allowing cells to overcome such damage is DNA damage bypass and post-replication repair.
However, this process has to be very tightly regulated as it can itself lead to genomic instability if not correctly controlled. Prof. Ulrich will investigate how this regulation occurs by developing new methods and technologies that will allow her to introduce DNA damage at specific locations in cell genomes. How this damage is processed will subsequently be imaged in live cells.
Particular attention will be paid to determining how post-translational modifications of the DNA-clamp protein PCNA coordinate the process of post-replication repair in conjunction with other interacting proteins. The award will fund this research for five years and will support a total of three postdoctoral researchers, two PhD students and a technician.
ERC Advanced Grants support projects that are highly ambitious, pioneering and unconventional. They are awarded to recognised research leaders proposing projects with the possibility of producing major breakthroughs of importance to a wide range of fields. More information about the award scheme can be found at http://erc.europa.eu/advanced-grants.Institute for Molecular Biology gGmbH (IMB)
Petra Giegerich | idw
Tracking down pest control strategies
31.01.2018 | Technische Universität Dresden
Polymers and Fuels from Renewable Resources
29.01.2018 | DECHEMA Gesellschaft für Chemische Technik und Biotechnologie e.V.
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