When DNA is replicated it is vulnerable to decay; the ability of cells to deal with this stress is a major factor in protecting our genomes from instability and cancer. A key mechanism allowing cells to overcome such damage is DNA damage bypass and post-replication repair.
However, this process has to be very tightly regulated as it can itself lead to genomic instability if not correctly controlled. Prof. Ulrich will investigate how this regulation occurs by developing new methods and technologies that will allow her to introduce DNA damage at specific locations in cell genomes. How this damage is processed will subsequently be imaged in live cells.
Particular attention will be paid to determining how post-translational modifications of the DNA-clamp protein PCNA coordinate the process of post-replication repair in conjunction with other interacting proteins. The award will fund this research for five years and will support a total of three postdoctoral researchers, two PhD students and a technician.
ERC Advanced Grants support projects that are highly ambitious, pioneering and unconventional. They are awarded to recognised research leaders proposing projects with the possibility of producing major breakthroughs of importance to a wide range of fields. More information about the award scheme can be found at http://erc.europa.eu/advanced-grants.Institute for Molecular Biology gGmbH (IMB)
Petra Giegerich | idw
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Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.
Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...
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