The German Research Foundation has approved funding for the Department of Internal Medicine II of the Mainz University Medical Center to promote the further study of the interrelations between the immune system and cardiovascular system disorders. The main focus of the current research project is on the pathogenesis of high blood pressure and arteriosclerosis.
PD Dr. Philip Wenzel, cardiologist and senior physician at the Department of Internal Medicine II, will use the about EUR 300,000 he has been granted for the next 36 months for staff resources and consumables. "We want to pursue the fascinating question of how the blood pressure hormone angiotensin II and the mediators of inflammation, in particular interferon gamma, interact in the pathogenesis of vascular diseases," said Wenzel.
In recent years, it has become increasingly clear that inflammatory cells, which are normally responsible for defending the body against pathogens, are also involved in the development of such frequently encountered disorders as hypertension, heart attack, stroke, and so-called 'window shopping syndrome' or intermittent claudication.
It is possible that many of the medications used to treat these illnesses, such as statins and ACE inhibitors, are only as effective as they are because they actually moderate these inflammatory processes. "Through our research, we hope to establish the foundations on which targeted anti-inflammatory therapies for arteriosclerosis can be developed and used in the future," Wenzel continued.
The successful acquisition of third-party funds is also attributable to the strategy adopted by the University Medical Center of Johannes Gutenberg University Mainz (JGU), namely that of establishing specialized research units. Within this context, the research team led by PD Dr. Philip Wenzel has managed to form partnerships that are important for the future of translational medicine.
"The work of the Research Unit Vascular Prevention and the establishment of the Center for Thrombosis and Hemostasis (CTH) with the support of the Mainz Heart Foundation have created an environment in which applications to the German Research Foundation have a greater chance of success," said Professor Dr. Thomas Münzel, Founding Director of the CTH and Coordinator of the Research Unit Vascular Prevention at the Mainz University Medical Center.
Petra Giegerich | idw
Understanding the fruit fly’s nose
24.11.2015 | Schweizerischer Nationalfonds SNF
Fighting Parkinson's disease: 1.25 million Euros for young Tübingen-based researcher
16.11.2015 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE)
Nerve cells cover their high energy demand with glucose and lactate. Scientists of the University of Zurich now provide new support for this. They show for the first time in the intact mouse brain evidence for an exchange of lactate between different brain cells. With this study they were able to confirm a 20-year old hypothesis.
In comparison to other organs, the human brain has the highest energy requirements. The supply of energy for nerve cells and the particular role of lactic acid...
In laser material processing, the simulation of processes has made great strides over the past few years. Today, the software can predict relatively well what will happen on the workpiece. Unfortunately, it is also highly complex and requires a lot of computing time. Thanks to clever simplification, experts from Fraunhofer ILT are now able to offer the first-ever simulation software that calculates processes in real time and also runs on tablet computers and smartphones. The fast software enables users to do without expensive experiments and to find optimum process parameters even more effectively.
Before now, the reliable simulation of laser processes was a job for experts. Armed with sophisticated software packages and after many hours on computer...
Researchers at Heidelberg University have devised a new way to study the phenomenon of magnetism. Using ultracold atoms at near absolute zero, they prepared a...
AWI researchers’ unique 15-year observation series reveals how sensitive marine ecosystems in polar regions are to change
The warming of arctic waters in the wake of climate change is likely to produce radical changes in the marine habitats of the High North. This is indicated by...
Berkeley Lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier
Glioblastoma multiforme, a cancer of the brain also known as "octopus tumors" because of the manner in which the cancer cells extend their tendrils into...
17.11.2015 | Event News
21.10.2015 | Event News
20.10.2015 | Event News
25.11.2015 | Life Sciences
25.11.2015 | Power and Electrical Engineering
25.11.2015 | Life Sciences