Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Eva-Maria and Eckhard Mandelkow have been awarded the Potamkin Prize

15.04.2011
Targets for Alzheimer therapy

Drs Eva-Maria and Eckhard Mandelkow, researchers at the Max Planck Unit for Structural Molecular Biology at DESY (Hamburg) and at the German Center for Neurodegenerative Diseases (DZNE) in Bonn, have been honored with the Potamkin Prize from the American Academy of Neurology (AAN) for their contributions to the field of dementia research.

The award ceremony takes place on 14 April at the Annual Meeting of the AAN in Honolulu (Hawaii). Eva-Maria and Eckhard Mandelkow share the prize, endowed with 100 000 U.S. dollars, with Dennis Dickson (Mayo Clinic, Jacksonville, Florida). The Potamkin Prize is one of the most prestigious awards in the field of dementia research. Since 1988, this important scientific honor is donated by the Potamkin entrepreneurial family from New York.

Together with their team, Eva-Maria and Eckhard Mandelkow have achieved major breakthroughs in Alzheimer research through their work on a protein termed tau. In the normal state tau strengthens the cytoskeleton in neurons and is involved in the transport of cell organelles. But very early in Alzheimer's disease it changes, becomes detached from the cytoskeleton and lumps together as cellular debris.

In their seminal work Eva-Maria and Eckhard Mandelkow investigated the mechanism of pathological tau aggregation and showed which parts of the protein are crucial for this process. Insights from this research then allowed them to investigate the consequences of tau protein aggregation in nerve cells in more detail using mouse and cellular models. The result showed that only forms of tau that are capable of aggregation destroy the synapses of nerve cells. If these forms of tau accumulate in neurons the mice perform poorly in learning and memory tests, thus showing typical symptoms of Alzheimer's disease. If the production of toxic tau in the cells of the mice is halted, synapses regenerate and the mice recover from their memory disorder. This crucial observation shows that the disease process is in principle reversible. With this work Eva-Maria and Eckhard Mandelkow provide an important starting point for the development of potential therapies. Their investigations on tau structure and their mouse experiments now allow the identification of drugs that counteract the toxic properties of tau and - at least in mice - can combat cognitive impairment.

Dr. Eckhard Mandelkow studied physics and earned his doctorate at the Max Planck Institute for Medical Research in Heidelberg on the structure of virus proteins. In his postdoctoral training at Brandeis University (Massachusetts, USA) he looked into proteins of the cytoskeleton and then continued this line of research with a focus on the structure and function of neuronal proteins, especially of motor proteins and tau proteins and their pathological changes during neurodegeneration. He is head of a laboratory of the Max Planck Society at the German Electron Synchrotron DESY and is currently building a new research group at the DZNE site in Bonn.

Dr. Eva-Maria Mandelkow studied medicine and worked for several years as physician in the clinic and then shifted her focus to basic research. She earned her doctorate at the Max Planck Institute for Medical Research in Heidelberg on a topic in muscle physiology. In subsequent research stays at Brandeis University (Massachusetts, USA), Scripps Research Institute (La Jolla, California) and at the MRC Laboratory in Cambridge (United Kingdom) she worked on proteins of the cytoskeleton. Eva-Maria Mandelkow heads a research group at the Max Planck lab in Hamburg, which deals with cell and mouse models of Alzheimer's disease. She also moves to the DZNE in Bonn as a group leader in 2011.

Contact information:
Drs. Eva-Maria und Eckhard Mandelkow
Max Planck Research Unit for Structural Molecular Biology
c/o DESY, Notkestrasse 85, 22607 Hamburg
German Center for Neurodegenerative Diseases (DZNE)
Ludwig-Erhard-Allee 2, 53175 Bonn
Tel: +49 (0)40-89982801, +49 (0)228-43302-263
Email: office@mpasmb.desy.de, mandelkow@dzne.de
Dr. Katrin Weigmann
German Center for Neurodegenerative Diseases (DZNE)
Press- and Public Relations
Tel: +49 (0) 228 43302 /263
Mobil: +49 (0) 173 – 5471350
Email: katrin.weigmann@dzne.de

Katrin Weigmann | idw
Further information:
http://www.dzne.de
http://www.mpasmb-hamburg.mpg.de
http://www.aan.com/science/awards/?fuseaction=home.info&id=13

More articles from Awards Funding:

nachricht Innovation Award of the United Nations Environment Programme for PhD Student from ZMT
22.03.2018 | Leibniz-Zentrum für Marine Tropenforschung (ZMT)

nachricht ERC Project set to boost application of adhesive structures
19.03.2018 | INM - Leibniz-Institut für Neue Materialien gGmbH

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

Im Focus: Gamma-ray flashes from plasma filaments

Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.

The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

Quantum Technology for Advanced Imaging – QUILT

24.04.2018 | Information Technology

AWI researchers measure a record concentration of microplastic in arctic sea ice

24.04.2018 | Earth Sciences

Complete skin regeneration system of fish unraveled

24.04.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>