Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Europe wide cooperation on spinal cord injury research receives 1.34 Million Euros grant

12.12.2016

Support for translational research: Europe wide cooperation on spinal cord injury research receives 1.34 Million Euros grant

Six European research teams including Dr. Michell Reimer and his team at the DFG-Center for Regenerative Therapies Dresden (CRTD) - Cluster of Excellence at the TU Dresden, received a 1.34 Million Euros ERA NET NEURON Grant for their research on spinal cord injury funded by the European Commission. The funding will start in 2017.


Dr. Michell M. Reimer

© CRTD


Countries of involved European partners

© CRTD

Dresden. Spinal cord injury results from trauma to the vertebral column, usually caused by accidents during sport activities or driving. Injury of the spinal cord is a devastating condition for the individuals who suffer not only from paralysis but also chronic pain and impairment of bodily functions such as bowel and bladder control. In addition to the physical aspects of this condition, the psychological impact is tremendous. According to the World Health Organization (WHO)*, as many as 500,000 people suffer a spinal cord injury each year*.

Humans do not regain spinal cord function after injury. However, zebrafish have the remarkable ability to functionally recover from spinal cord injury. They repair injured connections, replace damaged motor neurons and oligodendrocytes, enabling them to regain full movement within four weeks after injury. This grant now allows six European partnering institutions from Germany, France, Great Britain, Poland and Belgium to use this tropical fish to identify novel targets and mechanisms to improve the functional recovery after a spinal cord injury, test these targets in mammals and translate the findings into the human spinal cord cells. Along with the CRTD, the collaborator team includes researchers from the French National Institute of Health and Medical Research (Inserm), the University Hospital Carl Gustav Carus Dresden, the Free University of Brussels (VUB) and the Nencki Institute of Experimental Biology of the Polish Academy of Sciences. The complete project is coordinated by the University of Edinburgh (UK).

Alongside this research, the collaborators work on developing new techniques to analyze changes within the spinal cord and tools to modify identified targets. “This unique consortium of six groups in five countries combines laboratories that would not have been able to work together outside of the European Research Area Network for Neuroscience Research (ERA-NET NEURON) funding program. It is truly exciting to be part of this team and I am certain that our work will have a significant impact on spinal cord injury research”, Dr. Reimer explains. The collaborators hope their findings will reveal new therapies that could improve the lives of patients with spinal cord injury.

The study is funded by the European Commission through the European Research Area Network for Neuroscience Research (ERA-NET NEURON) and co-funded through national funding agencies. Lead researcher Professor Catherina Becker, Director of the University of Edinburgh’s Centre for Neuroregeneration, said: “This exciting project brings together leading experts from across Europe to explore the intrinsic capacity of the spinal cord to repair itself. We hope this will eventually lead to urgently needed therapies for people who have damage to their spinal cord, either from disease or injury.”

Before becoming a research group leader at the CRTD in 2014, biologist Michell Reimer worked for five years as a Post Doctoral Fellow at the Centre for Neuroregeneration and the Centre for Cognitive and Neural Systems at the University of Edinburgh (UK). From 2005-2008, Michell Reimer completed his PhD in the field of neuroscience at the Centre for Neuroregeneration, University of Edinburgh and the University Hamburg, Germany.

*http://www.who.int/mediacentre/news/releases/2013/spinal-cord-injury-20131202/en...

Research group on the CRTD website
http://www.crt-dresden.de/research/research-groups/core-groups/crtd-core-groups/...

Publications
Barreiro-Iglesias A., Mysiak, K.S., Scott, A.L., Reimer, M.M., Yang, Y., Becker, C.G., Becker, T. (2015) Serotonin Promotes Development and Regeneration of Spinal Motor Neurons in Zebrafish. (Cell Reports, 13(5): 924-932)

Wishart T.M.*, Mutsaers C.A.*, Riessland M.*, Reimer M.M.*, Hunter G.*, Hannam M.L., Eaton S.L., Fuller H.R., Roche S.L., Somers E., Morse R., Young P.J., Lamont D.J., Hammerschmidt M., Joshi A., Hohenstein P., Morris G.E., Parson S.H., Skehel P.A., Becker T., Robinson I.M., Becker C.G., Wirth B., Gillingwater T.H. (2014) Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy. (J Clin Invest. 2014 Mar 3. pii: 71318. doi: 10.1172/JCI71318.) * These authors contributed equally

Reimer M.M., Norris A., Patani R., Zhong Z., Ohnmacht J., Dias T.B., Kuscha V., Scott A.L., Chen Y., Frazer S.L., Wyatt C., Higashijma S., Patton L., Panula P., Chandran S., Becker T., Becker C.G.(2013) Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Developmental Cell, Volume 25, Issue 5, 478-491

Reimer M.M., Kuscha V., Wyatt C., Sörensen I., Frank R.E., Knüwer M., Becker T., Becker C.G. (2009) Sonic hedgehog is a polarized signal for motor neuron regeneration in adult zebrafish.
J Neurosci. 29:15073-82.

Reimer M.M., Sörensen I., Frank R.E., Chong, L., Becker C.G.*, Becker T.* (2008)
Motor neuron regeneration in adult zebrafish. J Neurosci. 28:8510-16.

Press Contact
Franziska Clauß, M.A.
Press Officer
Phone: +49 351 458 82065
E-Mail: franziska.clauss@tu-dresden.de

Founded in 2006, the DFG Research Center for Regenerative Therapies Dresden (CRTD), Cluster of Excellence at the TU Dresden has now passed the second phase of the Excellence Initiative which aims to promote top-level research and improve the quality of German universities and research institutions. The goal of the CRTD is to explore the human body's regenerative potential and to develop completely new, regenerative therapies for hitherto incurable diseases. The key areas of research include haematology and immunology, diabetes, neurodegenerative diseases, and bone regeneration. At present, eight professors and ten group leaders are working at the CRTD – integrated into an interdisciplinary network of 87 members at seven different institutions within Dresden. In addition, 21 partners from industry are supporting the network. The synergies in the network allow for a fast translation of results from basic research to clinical applications.

www.crt-dresden.de

Franziska Clauß | idw - Informationsdienst Wissenschaft

More articles from Awards Funding:

nachricht Fraunhofer HHI receives AIS Technology Innovation Award 2018 for 3D Human Body Reconstruction
17.01.2018 | Fraunhofer-Institut für Nachrichtentechnik, Heinrich-Hertz-Institut, HHI

nachricht Inspired by nature - scalable chemical factory due to photomicroreactors
11.01.2018 | DECHEMA Gesellschaft für Chemische Technik und Biotechnologie e.V.

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Optical Nanoscope Allows Imaging of Quantum Dots

Physicists have developed a technique based on optical microscopy that can be used to create images of atoms on the nanoscale. In particular, the new method allows the imaging of quantum dots in a semiconductor chip. Together with colleagues from the University of Bochum, scientists from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute reported the findings in the journal Nature Photonics.

Microscopes allow us to see structures that are otherwise invisible to the human eye. However, conventional optical microscopes cannot be used to image...

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Researchers reveal how microbes cope in phosphorus-deficient tropical soil

23.01.2018 | Earth Sciences

Opening the cavity floodgates

23.01.2018 | Life Sciences

Siberian scientists suggested a new method for synthesizing a promising magnetic material

23.01.2018 | Materials Sciences

VideoLinks Science & Research
Overview of more VideoLinks >>>