Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Brupbacher Prize goes to B. Vogelstein & J. Hoeijmakers for research on colorectal and skin cancer

17.02.2011
Today, the Charles Rodolphe Brupbacher Prize for Cancer Research 2011 goes to two researchers who have contributed to better understanding of the genetics underlying the growth of tumors.

Oncologist Bert Vogelstein has demonstrated how sequential accumulation of mutations leads to colorectal cancer, and Jan H. Hoeijmakers has conducted breakthrough research in xeroderma, a hereditary disease causing skin cancer.

For the tenth time, the Charles Rodolphe Brupbacher Prize will be awarded in conjunction with an international symposium. The prize of 100,000 Swiss francs for each scientist, is one of the world’s most prestigious honors in cancer research. The prize is awarded every two years to investigators who have made outstanding contributions to oncology. The symposium will also honor five junior researchers who will receive a Young Investigator Award.

This year's Brupbacher Prize goes to Prof. Bert Vogelstein of the John Hopkins University in Baltimore (USA) and to Prof. Jan. H. Hoeijmakers of Erasmus University, Rotterdam (Netherlands). The findings of both researchers have contributed greatly to the understanding of the genetic basis of tumor growth. Bert Vogelstein's main area of research is colorectal cancer, Jan Hoeijmakers' is skin cancer. The particular significance of their findings lies in their general relevance: Cancer of the colon and rectum is closely linked to lifestyle of Western populations and is the second-leading cause of cancer-related deaths in Europe. Hoeijmakers’ findings do not only shed light on skin tumors, but also on premature aging.

Bert Vogelstein

Bert Vogelstein ranks among the most-quoted scientists in the field of biomedicine. He is best-known for his groundbreaking work on the genesis of cancer of the colon. Tumors in the large intestine (colon) lend themselves particularly well to analysis because their progression from a benign growth to a malignant tumor can be clinically observed by means of colonoscopies.

Vogelstein has observed that initial, small accumulations of atypical cells are caused by a mutation of the APC gene, a tumor-suppressor gene that controls cell division. The mutation of the APC gene is also responsible for inherited familial adenomatous polyposis, a disease characterized by a great number of polyps in the intestinal wall. If not removed, these polyps can develop into colon cancer.

Additional mutations activate genes coding for growth factors (oncogenes).as well as in other tumor suppressor genes. All of these DNA mutations mediate a slow but steady growth from initially small, then larger benign polyps that then progress into a carcinoma. Although it takes an average of 17 years for a small polyp to develop into a carcinoma, the process then accelerates, leading typically within two more years to a highly malignant carcinoma that metastasizes to regional lymph nodes and distant organs.

Vogelstein's findings on the sequential accumulation of mutations and tumor growth have received wide-spread recognition and provide the basis for prevention, early diagnosis and treatment of colorectal cancer. Vogelstein has recently begun analyzing entire cancer genomes, i.e. the sum of all genes in a cell. Understanding the genetic make-up of a tumor provides the basis for personalized tumor therapy, a major goal in clinical oncology.

Jan H. Hoeijmakers

Jan Hoeijmakers has made an outstanding contribution by elucidating the molecular basis of hereditary diseases caused by defective DNA repair. There are multiple pathways for the repair of damaged DNA. If left unrepaired, this increases the risk of several diseases, including cancer. Dr. Hoeijmakers has performed innovative research on xeroderma pigmentosum, a hereditary skin disease that is characterized by extreme sensitivity to UV rays and the development of multiple, often malignant tumors in skin regions exposed to sunlight. Ultraviolet rays cause damage involving chemical links between coding DNA bases, particularly thymine. During cell division and in the absence of efficient repair, this leads to permanent mutations in daughter cells. Patients affected by xeroderma pigmentosum demonstrate a reduced DNA repair capacity.

Hoeijmakers identified and characterized multiple genes involved in the repair process. He was able to show that certain forms of limited DNA repair capacity can bring about the exact opposite of a tumor, namely premature aging.

A complex DNA repair system ensures the stability of our genome. Jan Hoeijmakers has earned international recognition for having identified key aspects of the molecular basis of DNA repair and the role it plays in both, the development of tumors and in premature aging.

The foundation:
The Charles Rodolphe Brupbacher Foundation was founded in 1991 by Mme. Frédérique Brupbacher in memory of her husband, Charles Rodolphe Brupbacher. The foundation is affiliated with the Faculty of Medicine of the University of Zurich. More information on the foundation is available at www.brupbacher-stiftung.ch
Contact information:
Prof. Paul Kleihues
C.R. Brupbacher Stiftung
c/o Dean's Office, Faculty of Medicine
University of Zurich
Phone: +41 79 738 34 72
E-Mail: brupbacher-stiftung@dekmed.uzh.ch

Beat Müller | idw
Further information:
http://www.mediadesk.uzh.ch/articles/2011/brupbacher-preis-2011_en.html
http://www.mediadesk.uzh.ch/articles/2011/brupbacher-preis-2011.html

More articles from Awards Funding:

nachricht Extensive Funding for Research on Chromatin, Adrenal Gland, and Cancer Therapy
28.06.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

nachricht Otto Hahn Medal for Jaime Agudo-Canalejo
21.06.2017 | Max-Planck-Institut für Kolloid- und Grenzflächenforschung

All articles from Awards Funding >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Physicists Design Ultrafocused Pulses

Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.

Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...

Im Focus: Carbon Nanotubes Turn Electrical Current into Light-emitting Quasi-particles

Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers

Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...

Im Focus: Flexible proximity sensor creates smart surfaces

Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.

At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...

Im Focus: 3-D scanning with water

3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects

A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

 
Latest News

Programming cells with computer-like logic

27.07.2017 | Life Sciences

Identified the component that allows a lethal bacteria to spread resistance to antibiotics

27.07.2017 | Life Sciences

Malaria Already Endemic in the Mediterranean by the Roman Period

27.07.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>