Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smart Capsule For Insulin

30.05.2005


The Moscow chemists have suggested a way to produce insulin in pills instead of injections. They have developed polymeric capsules that would protect insulin from destructive effect of digestive juices. The research has been accomplished with financial support of the Ministry of Industry, Science and Technology of Russia within the framework of international scientific cooperation.



Once insulin appeared, diabetes mellitus is no longer a verdict for the patients. However, to control the sugar level in blood, diabetics have to make injections on a regular basis up to several times a day, which undoubtedly makes their life more difficult. The lack of timely injection may result in fatal outcome. The pills would significantly simplify their life. However, the fact that insulin gets quickly destroyed when it appears in acid medium of the stomach does not exclude but significantly complicates creation of pilled insulin. Researchers of the Chemical Faculty, Lomonosov Moscow State University, have found the way to protect insulin from digestive juices’ destructive effect and to preserve the ability to perform its function.

To introduce insulin in the organism, the Russian chemists suggested that multi-layer polymeric capsules should be used. These polymeric capsules are stable and remain intact in acid medium, and in neutral medium, capsules gradually excrete insulin.


To create such capsules, the researchers used two polymers - positive protamin and negative dextransulphate. They formed layers in series one upon the other according to the plus towards minus principle and made a multi-layer covering around the insulin filling, which makes up to 85 percent of the entire microparticle.

Insulin covered by protective capsule is stable at pH from 1.7 to 5 units, when pH increases higher than 5 units, insulin gets released. Further pH increase up to 8 units results in accelerated protein release rate. Such behavior of particles occurs due to the fact that at pH higher than 5.5 insulin acquires negative charge and its bond with the negatively charged polymer of the first layer - dextransulphate – gets destroyed.

Such pH-dependence of protective polymeric capsules provides fundamental capability to create insulin in pills. In the stomach, where medium is extremely acid, these capsules would protect the insulin molecule and would not allow its destruction. Having gone through the stomach and having reached the small intestine and ileum, where pH reaches 6 to 8 units, capsules will start to excrete insulin intensely. In thin intestines, insulin can penetrate blood. Therefore, the capsule determines by itself where insulin should be retained in closed form and where it should be released.

The polymers used to create capsules belong to natural biodegradable polymers. After utilization they get easily destroyed by enzymes and removed from the organism without causing any harm to health.

Sergey Komarov | alfa
Further information:
http://www.informnauka.ru

More articles from Automotive Engineering:

nachricht Self-driving cars for country roads
07.05.2018 | Massachusetts Institute of Technology, CSAIL

nachricht When your car knows how you feel
20.12.2017 | FZI Forschungszentrum Informatik am Karlsruher Institut für Technologie

All articles from Automotive Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>