The insecticide would work by interfering with an enzyme found in the nervous systems of mosquitoes and many other organisms, called acetylcholinesterase.
Existing insecticides target the enzyme but affect a broad range of species, said entomologist Jeff Bloomquist, a professor in UF’s Emerging Pathogens Institute and its Institute of Food and Agricultural Sciences.
Acetylcholinesterase helps regulate nervous system activity by stopping electrical signaling in nerve cells. If the enzyme can’t do its job, the mosquito begins convulsing and dies. The research team’s goal is to develop compounds perfectly matched to the acetylcholinesterase molecules in malaria-transmitting mosquitoes, he said.
“A simple analogy would be that we’re trying to make a key that fits perfectly into a lock,” Bloomquist said. “We want to shut down the enzyme, but only in target species.”
Malaria is spread by mosquitoes in the Anopheles genus, notably Anopheles gambiae, native to Africa. The disease is common in poor communities where homes may not have adequate screens to keep flying insects out.
Malaria is caused by microscopic organisms called protists, which are present in the saliva of infected female mosquitoes and transmitted when the mosquitoes bite.
Initial symptoms of the disease can include fever, chills, convulsions, headaches and nausea. In severe cases, malaria can cause kidney failure, coma and death. Worldwide, malaria infected about 219 million people in 2010 and killed about 660,000, according to the Centers for Disease Control and Prevention. About 90 percent of those infected lived in Africa.
Bloomquist and colleagues at Virginia Tech, where the project is based, are trying to perfect mosquito-specific compounds that can be manufactured on a large scale and applied to mosquito netting and surfaces where the pests might land.
It will take at least four to five years before the team has developed and tested a compound enough that it’s ready to be submitted for federal approval, Bloomquist said.
The team recently published a study in the journal Pesticide Biochemistry and Physiology comparing eight experimental compounds with commercially available insecticides that target the enzyme.
Though they were less toxic to mosquitoes than commercial products, the experimental compounds were far more selective, indicating researchers are on the right track, he said.
“The compounds we’re using are not very toxic to honeybees, fish and mammals, but we need to refine them further, make them more toxic to mosquitoes and safer for nontarget organisms,” he said.
Funding for the project came from a five-year, $3.6 million grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.
In Florida, malaria was a significant problem in the early 20th century, transmitted by native Anopheles mosquitoes. The disease has been greatly curtailed via mosquito-control practices but even today, cases are occasionally reported in the Sunshine State.Source: Jeff Bloomquist, email@example.com, 352-273-9417
Tom Nordlie | Newswise
Forest Management Yields Higher Productivity through Biodiversity
14.10.2016 | Technische Universität München
Farming with forests
23.09.2016 | University of Illinois College of Agricultural, Consumer and Environmental Sciences (ACES)
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Earth Sciences
24.10.2016 | Life Sciences
24.10.2016 | Physics and Astronomy