This has been shown in research by Elio Schijlen at Plant Research Internationa, part of Wageningen University and Research Centre in the Netherlands. Schijlen demonstrated that this approach enables tomatoes to produce larger amounts of specific flavonoids and to let tomatoes produce flavonoids they cannot produce by nature. On the basis of the research Schijlen obtained HIS his PhD-degree on Thursday 8 February at the University of Amsterdam.
The results of this research show that genetic modification is a possible approach to further increase the health promoting value of vegetables and fruit. Flavonoids are frequently occurring and important metabolites in plants. About 6000 different flavonoids are known to be involved in various natural processes. The colour of flowers and ripe fruits, e.g., are often caused by flavonoids. But flavonoids also play an important role in other plant processes such as pollen production, disease resistance, and protection against UV radiation.
Because flavonoids are so frequently occurring in plants, they are a permanent component of our food. Part of the health promoting effects of vegetables and fruit is attributed to flavonoids. It may therefore be attractive to increase the amount of flavonoids and/or change their composition.
This was why Schijlen, working at Plant Research International of Wageningen UR, studied the possibilities of steering the production of flavonoids by a directed change of the biosynthesis route via genetic modification. He followed various approaches to achieve this. One approach was to investigate the possibility of increasing the amount of flavonoids in tomato by means of so-called transcription factors, proteins involved in regulating gene activity.
Schijlen also investigated the possibility to produce new flavonoids in tomatoes which might increase the health promoting properties of tomatoes. For this purpose he used genes form other crops such as grape and alfalfa, genes that are involved in certain steps in the biosynthesis of flavonoids in these crops.
Both approaches were found to be successful. Through genetic modification Schijlen succeeded in developing tomatoes not only with more flavonoids but also with new flavonoids.
Via biochemical analysis Schijlen demonstrated an increased antioxidant action of tomatoes with flavones and more flavonoles, two specific groups of flavonoids. In cooperation with scientists of BASF Plant Science and TNO, the potential health promoting effects of these tomatoes were tested in feeding studies with mice. Blood analyses showed that that the tomatoes with increased flavonoids had a stronger positive effect on blood properties that are characteristic of a reduced risk of cardiovascular disorders.
With his results, Schijlen has shown that genetic modification can further increase the health promoting effects of vegetables and fruit.
Jac Niessen | alfa
New gene for atrazine resistance identified in waterhemp
24.02.2017 | University of Illinois College of Agricultural, Consumer and Environmental Sciences
Researchers discover a new link to fight billion-dollar threat to soybean production
14.02.2017 | University of Missouri-Columbia
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News