Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Which genes cause deafness in dogs?

04.12.2013
TiHo researchers discover genes for congenital sensorineural deafness in Dalmatians.

More than 90 dog breeds can suffer from congenital sensorineural deafness. Dog breeds carrying certain gene variants for piebald spotting or the so-called merle factor which disturbs the synthesis of colour pigments and causes a brightening of the coat colour are particularly affected.


Of all of the breeds of dog, the inheritance of sensorineural deafness has thus far been most extensively investigated in Dalmatians.

Foto: majtas/Fotolia

Professor Ottmar Distl and Susanne Kluth from the Institute for Animal Breeding and Genetics of the University of Veterinary Medicine Hannover (TiHo) investigated the genetic causes for congenital sensorineural deafness in 235 Dalmatians. In order to do this, they screened more than 170.000 genetic variants distributed across the entire genome for sensorineural deafness. Their results provide the basis for a better understanding of the development of sensorineural deafness.

The researchers published them in the November issue of the online specialist magazine PLoS ONE (http://dx.plos.org/10.1371/journal.pone.0080642).

The genetic mechanisms which cause sensorineural deafness are very complex. Various gene variants are able to trigger the disease. “More than 90 percent of dogs with two or more gene variants for sensorineural deafness are affected by sensorineural deafness”, the researchers say. In their studies, the scientists found genes which affect the development of different structures in the inner ear. This includes the tectorial membrane, which is located within the cochlea, and the organ of Corti with its hair cells which convert acoustic signals into nerve signals and transmit them to the auditory nerve. Animals lacking the skin pigment cells known as melanocytes in their inner ears are also affected by sensorineural deafness.

Melanocytes have to migrate into the inner ear in order to complete important tasks for the formation of the acoustic hearing signal. Until now, this could only be verified in mouse models and a very rare natural mutation of white cattle.

The genetic knowledge now available provides the researchers of the University of Veterinary Medicine in Hannover with the basis to decipher the causes for congenital sensorineural deafness. Using the latest methods of genome analysis, they now start to compare the genome of dogs suffering from congenital sensorineural deafness with that of normally hearing dogs. The aim is to investigate congenital sensorineural deafness in as many dog and cat breeds as possible. “Only the knowledge of the genetic causes of the disease will help dog and cat breeders to prevent this inherited disease effectively and to organize their breeding programs appropriately, so our research is an important contribution to animal welfare”, says Distl. Scientists are currently developing a genome-wide test to detect sensorineural deafness. Dalmatian breeders can already ship EDTA blood samples (addition of EDTA prevents clotting of the blood) to the Institute for Animal Breeding and Genetics in Hannover, Germany (http://www.tiho-hannover.de/de/kliniken-institute/institute/institut-fuer-tierzu...). Breeders who want to support the development of tests for further dog and cat breeds can help by providing sample material (EDTA blood) and brainstem auditory evoked response (BAER) test results.

Of all of the breeds of dog, the inheritance of sensorineural deafness has thus far been most extensively investigated in Dalmatians. In the breeds Australian Cattle Dog, Boston Terrier, English Cocker Spaniel, English Setter, Jack Russell Terrier, Australian Shepherd and Border Collies, sensorineural deafness occurs more frequently when the animals are bred with stronger piebald spotting.

Original publication
Congenital sensorineural deafness in Dalmatian dogs associated with quantitative trait loci
Susanne Kluth, Ottmar Distl
PLOS ONE, DOI: 10.1371/journal.pone.0080642
Contact
Professor Dr. Ottmar Distl
University of Veterinary Medicine Hannover
Institute for Animal Breeding and Genetics
Tel.: +49 511 953-8875
ottmar.distl@tiho-hannover.de

Sonja von Brethorst | idw
Further information:
http://www.tiho-hannover.de

More articles from Agricultural and Forestry Science:

nachricht New insight into why Pierce's disease is so deadly to grapevines
11.06.2018 | University of California - Davis

nachricht Where are Europe’s last primary forests?
29.05.2018 | Humboldt-Universität zu Berlin

All articles from Agricultural and Forestry Science >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>