Japanese researchers have successfully developed the world's first imaging method for visualising the behaviour of nicotine-adenine dinucleotide derivative (NAD(P)H), a key coenzyme, inside cells. This feat could ultimately facilitate the diagnosis of cancer and liver dysfunction and help to elucidate the mechanisms of neurological disorders.
A Japanese research team led by Drs. Hirokazu Komatsu and Katsuhiko Ariga of the International Center for Materials Nanoarchitectonics, in collaboration with Professors Yutaka Shido and Kotaro Oka of Keio University, have developed the world's first method for visualising the coenzyme nicotine-adenine dinucleotide derivative (NAD(P)H) inside cells.
Fluorescent imaging of HeLa cell
Copyright : National Institute for Materials Science (NIMS)
Fluorescent imaging – used to identify and visualise cellular components by attaching a fluorescent substance – is an effective method for exploring vital phenomena.
Until now, however, the development of a method for visualising NAD(P)H, which plays a key role in various vital phenomena and diseases, has proven elusive due to the low reactivity of NAD(P)H to fluorescent substances.
The research group succeeded in developing a new fluorescent probe that specifically reacts with NAD(P)H, and achieved fluorescent imaging of NAD(P)H for the first time in the world, through the combined use of the new probe and an artificial promoter capable of promoting reactivity.
The new NADH imaging method could be used for various purposes, including: promoting early detection and supporting cancer treatment by detecting NADH leakage from invasive cancers; diagnosing liver dysfunction by detecting excessive NADH caused by cirrhosis of the liver; and elucidating the lack of NADH in patients with brain or neurological diseases such as Alzheimer's Disease, depression, and Parkinson's Disease.
The new method will also prove of great value in other life sciences research.
The research results will be published in a German scientific journal, Angewandte Chemie International Edition.
Mikiko Tanifuji | Research SEA News
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30.09.2016 | Oak Ridge National Laboratory
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29.09.2016 | National Institute for Materials Science
Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.
Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
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Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.
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The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
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With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
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