Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

World's first successful visualisation of key coenzyme

16.04.2014

Japanese researchers have successfully developed the world's first imaging method for visualising the behaviour of nicotine-adenine dinucleotide derivative (NAD(P)H), a key coenzyme, inside cells. This feat could ultimately facilitate the diagnosis of cancer and liver dysfunction and help to elucidate the mechanisms of neurological disorders.  

A Japanese research team led by Drs. Hirokazu Komatsu and Katsuhiko Ariga of the International Center for Materials Nanoarchitectonics, in collaboration with Professors Yutaka Shido and Kotaro Oka of Keio University, have developed the world's first method for visualising the coenzyme nicotine-adenine dinucleotide derivative (NAD(P)H) inside cells.


Fluorescent imaging of HeLa cell

Copyright : National Institute for Materials Science (NIMS)

Fluorescent imaging – used to identify and visualise cellular components by attaching a fluorescent substance – is an effective method for exploring vital phenomena.

Until now, however, the development of a method for visualising NAD(P)H, which plays a key role in various vital phenomena and diseases, has proven elusive due to the low reactivity of NAD(P)H to fluorescent substances.

The research group succeeded in developing a new fluorescent probe that specifically reacts with NAD(P)H, and achieved fluorescent imaging of NAD(P)H for the first time in the world, through the combined use of the new probe and an artificial promoter capable of promoting reactivity.

The new NADH imaging method could be used for various purposes, including: promoting early detection and supporting cancer treatment by detecting NADH leakage from invasive cancers; diagnosing liver dysfunction by detecting excessive NADH caused by cirrhosis of the liver; and elucidating the lack of NADH in patients with brain or neurological diseases such as Alzheimer's Disease, depression, and Parkinson's Disease.

The new method will also prove of great value in other life sciences research.

The research results will be published in a German scientific journal, Angewandte Chemie International Edition.

Associated links

http://www.nims.go.jp/eng/

Mikiko Tanifuji | Research SEA News
Further information:
http://www.researchsea.com

Further reports about: NADH coenzyme detecting diseases fluorescent liver neurological phenomena reactivity substances

More articles from Materials Sciences:

nachricht Melting solid below the freezing point
23.01.2017 | Carnegie Institution for Science

nachricht An innovative high-performance material: biofibers made from green lacewing silk
20.01.2017 | Fraunhofer-Institut für Angewandte Polymerforschung IAP

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists spin artificial silk from whey protein

X-ray study throws light on key process for production

A Swedish-German team of researchers has cleared up a key process for the artificial production of silk. With the help of the intense X-rays from DESY's...

Im Focus: Quantum optical sensor for the first time tested in space – with a laser system from Berlin

For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.

According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Breaking the optical bandwidth record of stable pulsed lasers

24.01.2017 | Physics and Astronomy

Choreographing the microRNA-target dance

24.01.2017 | Life Sciences

Spanish scientists create a 3-D bioprinter to print human skin

24.01.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>