Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Rigid growth matrix: a key to success of cardiac tissue engineering

16.04.2013
A new study by researchers at UCLA suggests that the elasticity of the physical matrix used for growing heart muscle cells outside of the body may be critical to the success of cardiac tissue engineering. The results were published in the journal Science and Technology of Advanced Materials this week.

Adult heart muscle is the least regenerative of human tissues. But embryonic cardiomyocytes (cardiac muscle cells) can multiply, with embryonic stem cells providing an endless reservoir for new cardiac tissue.

A new study by Nakano, Gimzewski and their co-workers at the University of California, Los Angeles (UCLA) suggests that the elasticity of the physical matrix used for growing cardiomyocytes outside of the body may be critical to the success of cardiac tissue engineering efforts.

Published in the journal Science and Technology of Advanced Materials Vol. 14, p. 025003 (http://iopscience.iop.org/1468-6996/14/2/025003), the study found that a stiff or rigid environment not only enhances the function of existing cardiomyocytes (as has previously been shown), but also promotes the generation of cardiomyocytes from embryonic stem (ES) cells. It may therefor be possible to grow new heart muscle tissue from stem cells by manipulating the stiffness of the medium they're grown in.

In living organisms, a type of adult stem cells called mesenchymal stem cells (MSCs) are extremely sensitive to the elasticity of different materials, when cultured outside the body. For example, soft growing matrices that mimic brain tissue promote the differentiation of MSCs into neurons, while rigid matrices that resemble bone tissue promote the differentiation of MSCs into bone cells.

In this study, the UCLA team examined the role of matrix elasticity on cardiac muscle development using mouse and human embryonic stem cells, which were grown on different substrates of a silicon-based organic polymer that varied in stiffness. The team found that rigid matrices promoted the generation of more cardiomyocytes cells from ES cells. In addition, ES-derived cardiomyocytes displayed functional maturity and synchronization of beating when cultured with cardiomyocytes harvested from a developing embryo.

The team recommends further research on how biophysical cues determine the fate of embryonic stem cells in order to improve cardiac tissue culture methods for regenerative medicine purposes.

For more information about this study, please contact:

Atsushi Nakano
Department of Molecular, Cell and Developmental Biology
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Jonsson Comprehensive Cancer Center
Molecular Biology Institute
University of California Los Angeles
Email: anakano@ucla.edu
Journal information
[1] Armin Arshi, Yasuhiro Nakashima, Haruko Nakano, Sarayoot Eaimkhong, Denis Evseenko, Jason Reed, Adam Z Stieg, James K Gimzewski and Atsushi Nakano, “Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells”, Science and Technology of Advanced Materials 14 (2013) 025003, doi:10.1088/1468-6996/14/2/025003.

Mikiko Tanifuji | Research asia research news
Further information:
http://iopscience.iop.org/1468-6996/14/2/025003
http://www.researchsea.com

More articles from Materials Sciences:

nachricht Triboelectric nanogenerators boost mass spectrometry performance
28.02.2017 | Georgia Institute of Technology

nachricht Nano 'sandwich' offers unique properties
28.02.2017 | Rice University

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

A better way to measure the stiffness of cancer cells

01.03.2017 | Health and Medicine

Exploring the mysteries of supercooled water

01.03.2017 | Physics and Astronomy

Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth

01.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>