Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New joint replacement material developed at MGH put to first clinical use

24.07.2007
New form of polyethylene will allow stronger, more versatile joint replacement

Massachusetts General Hospital (MGH) surgeons have performed the first total hip replacement using a joint socket lined with a novel material invented at the MGH. An advance over first-generation highly crosslinked polyethylene, which was also developed at MGH and significantly reduced a serious complication of early hip implants, the new material may be applied in replacements for a wider variety of joints in a more diverse group of patients.

“We think this material could be used for any joint in the body and in any implant design, even those demanding higher flexion and more mobility,” says Orhun Muratoglu, PhD, co-director of the Harris Orthopædics Biomechanics and Biomaterials Laboratory (OBBL) at MGH, who developed the new material in collaboration with scientists at the Cambridge Polymer Group.

Total replacements for hips and other joints were developed in the late 1960s, but it soon became apparent that hip implants could start loosening about 5 years after surgery and would eventually fail completely. A team led by William Harris, MD, DSc, now director emeritus of the MGH OBBL, investigated this complication and found that long-term friction of the implant’s head against the polyethylene-lined joint socket would break off small particles of polyethylene. The body’s immune system reacted against these foreign particles, eventually destroying adjacent bone tissue and causing the implant to loosen – a condition called periprosthetic osteolysis.

Harris and his colleagues, working with polymer chemists from MIT, found that high doses of radiation would “crosslink” the polyethylene, bonding molecules together to produce a much more durable material. The procedure also generates free radicals that could lead to oxidization and degradation of the implant, but the research team found that melting the material would eliminate free radicals. The first-generation highly crosslinked polyethylene was approved by the FDA for use in implants in 1999 and has been licensed to Zimmer, Inc.

However, the MGH researchers knew that the first-generation material had limitations in strength that made it unsuitable for some types of joint replacement implants. Subsequently, Muratoglu found that oxidation could be blocked by diffusing the antioxidant vitamin E throughout the polyethylene material. Both mechanical testing and animal studies have shown that the new material resists wear as well as the first generation and is much stronger. Vitamin-E-stabilized, highly crosslinked polyethylene has also received FDA approval for use in joint implants and has been licensed to both Zimmer and to Biomet, Inc., which made the implant used in the first surgical procedure on July 16.

“This material will allow us to offer our patients very long-term, high-performance joint replacements,” says Andrew A. Freiberg, MD, chief of the Arthoplasty Service in the MGH Department of Orthopædics, who performed the first implant with the new material. “It should be suitable for higher-stress applications in younger patients, those who are more active and those who are heavier.”

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu/

More articles from Materials Sciences:

nachricht Graphene origami as a mechanically tunable plasmonic structure for infrared detection
25.04.2018 | University of Illinois College of Engineering

nachricht Scientists create innovative new 'green' concrete using graphene
24.04.2018 | University of Exeter

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Why we need erasable MRI scans

New technology could allow an MRI contrast agent to 'blink off,' helping doctors diagnose disease

Magnetic resonance imaging, or MRI, is a widely used medical tool for taking pictures of the insides of our body. One way to make MRI scans easier to read is...

Im Focus: BAM@Hannover Messe: innovative 3D printing method for space flight

At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.

Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...

Im Focus: Molecules Brilliantly Illuminated

Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.

Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...

Im Focus: Spider silk key to new bone-fixing composite

University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.

Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.

Im Focus: Writing and deleting magnets with lasers

Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

IWOLIA: A conference bringing together German Industrie 4.0 and French Industrie du Futur

09.04.2018 | Event News

 
Latest News

World's smallest optical implantable biodevice

26.04.2018 | Power and Electrical Engineering

Molecular evolution: How the building blocks of life may form in space

26.04.2018 | Life Sciences

First Li-Fi-product with technology from Fraunhofer HHI launched in Japan

26.04.2018 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>