Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Liquid crystals show promise in controlling embryonic stem cells

09.03.2006


Liquid crystals, the same phase-shifting materials used to display information on cell phones, monitors and other electronic equipment, can also be used to report in real time on the differentiation of embryonic stem cells.

Differentiation is the process by which embryonic stem cells gradually turn into function-specific types of adult cells or so-called "cell lineages," including skin, heart or brain cells.

The main challenge facing stem cell research is that of guiding differentiation along these well-defined, controlled lineages. Stem cells grown in the laboratory tend to differentiate in an uncontrolled manner, resulting in a mixture of cells of little medical use.



Now, University of Wisconsin-Madison researchers at the NSF-funded Materials Research Science and Engineering Center (MRSEC) have shown that by straining mechanically the cells as they grow, it is possible to reduce significantly and almost eliminate the uncontrolled differentiation of stem cells.

In an article in the March issue of Advanced Functional Materials, the team reports on a liquid crystal-based cell culture system that promises new ways of achieving real-time control over interactions between synthetic materials and human embryonic stem cells, including the possibility of straining embryonic stem cells as they grow.

"Stem cells tend to be smaller and have a slightly more compact shape than the differentiated cells," says chemical and biological engineer Sean Palecek. "Differentiated cells appear to be much more spread and they appear to exert different levels of force on the matrix in which they are grown. That force can be read to a liquid crystal. Through simple changes of liquid crystal texture and color, our cell culture system is able to report, in real time, the cell interactions with the underlying support on which they are grown."

Currently, researchers have several methods of monitoring cell differentiation. The easiest, says Palecek, is to just look at the cells and use cell morphology as a cue. A more accurate method uses molecular markers. Antibodies are placed against these markers to determine if they bind to the cell. That system, while more accurate, does not provide real time data and cells often have to be killed in order to analyze the markers.

"This newly devised cell culture system enables a new paradigm in stem cell research," says chemical and biological engineer and MRSEC Director Juan de Pablo. "Ultimately, we hope to use liquid crystalline materials to transmit desired sets of physical and chemical cues to stem cells so as to control their differentiation, as well as report back specific responses of the cells or tissue.

"This research is also significant as an example of our unique effort to integrate advanced materials engineering and embryonic stem cell research, an effort that will help accelerate the rate at which the benefits of stem-cell based therapies are brought to society," de Pablo adds.

Sean Palecek | EurekAlert!
Further information:
http://www.engr.wisc.edu

More articles from Materials Sciences:

nachricht New design improves performance of flexible wearable electronics
23.06.2017 | North Carolina State University

nachricht Plant inspiration could lead to flexible electronics
22.06.2017 | American Chemical Society

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Supersensitive through quantum entanglement

28.06.2017 | Physics and Astronomy

X-ray photoelectron spectroscopy under real ambient pressure conditions

28.06.2017 | Physics and Astronomy

Mice provide insight into genetics of autism spectrum disorders

28.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>