Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New testing method developed to assess safety, health risks of nanomaterials

03.02.2006


UCLA researcher developing lab to help manufacturer testing



Shades of science fiction surround the potential of the booming nanotechnology industry - like Michael Crichton’s novel "Prey", which features tiny nano-robots threatening to take over the world. Fiction of course, but nanotechnology is rapidly expanding and promises to exceed the impact of the Industrial Revolution, projecting to become a $1 trillion market by 2015.

UCLA has developed a new testing method that would help manufacturers monitor and test the safety and health risks of engineered nanomaterials. Currently, no government or industry regulations exist for this emerging technology.


A review article in the Feb. 3 issue of the journal Science by Dr. Andre Nel, Professor of Medicine at the David Geffen School of Medicine at UCLA and a member of the California NanoSystems Institute (CNSI), presents a compelling discussion on the potential toxic effects of nanomaterials and the urgent need for developing safety testing.

Nanotechnology involves manipulating atoms to create tiny molecules, smaller than one one-thousandth the diameter of a human hair. ("Nano" means "one billionth of a meter"). At such a small size, materials exhibit unconventional physical and chemical properties that allow them to perform amazing new feats in the areas of electronics, optics, sensoring, material strength, catalysis, and drug delivery.

Engineered nanomaterials are already being used in sporting goods, tires, stain-resistant clothing, sunscreens, cosmetics, and electronics and will also be utilized increasingly in medicine for purposes of diagnosis, imaging and drug delivery.

The ability of nanotechnology to interact with biological materials leads to the possibility that they may be harmful to humans and the environment. Current understanding of the potential toxicity of nanoparticles is limited, but research indicates that some of these products may enter the human body and become toxic at the cellular level, in various body fluids, tissues, and/or organs.

Recognizing a need to develop a rational, science-based approach to nanotoxicology, Nel and his UCLA team have developed a new testing method to assess the safety and health risks of engineered nanomaterials. Nel is also establishing NanoSafety Laboratories Inc. (NSL) in association with CNSI at UCLA to help manufacturers assess the safety and risk profiles of engineered nanomaterials.

The testing model developed at UCLA is based on toxicity testing for occupational and air pollution particles, which include nanoparticles. Nanoparticles are the most toxic ingredient in these environmental pollutants. A mature toxicological science has emerged from the study of these particles, providing a framework for a predictive testing strategy applicable to engineered nanomaterials.

A predictive strategy is one in which a series of simple but high quality tests can be employed to predict which materials could be hazardous, and therefore speed up the process of classifying materials into those that are safe and those that could pose toxicity problems. This type of approach is similar to that used by the National Toxicology Program for evaluation of chemical agents.

Nel’s model predicts toxicity according to the ability of some nanoparticles to generate toxic oxygen radicals, which are highly reactive forms of oxygen that can cause tissue injury, including inflammation and other toxic effects. For air pollution particles, this injury can translate into asthma and atherosclerotic heart disease. Using this model, Nel’s laboratory has developed a series of tests to assess nanoparticle toxicity in non-biological environments as well as in tissue cultures and animal models.

"We can use the strong scientific foundation of air pollution particle testing to help understand the health impact of engineered nanoparticles and ensure safe manufacturing of nanoproducts," said Nel, co-director of the Southern California Particle Center and UCLA Asthma and Immunological Disease Center.

The review in Science addresses questions about occupational and inhalation exposures to nanoparticles and outlines the properties of nanomaterials that need to be considered for toxicity testing.

The impact of nanoparticle interactions with the body are dependent on their size, chemical composition, surface structure, solubility, shape, and how the individual nanoparticles amass together, according to Nel. Nanoparticles may modify the way cells behave and potential routes of exposure, include the gastrointestinal tract, skin and lungs. The three key elements of the toxicity screening strategy should include the physical and chemical characterization of nanomaterials, tissue cellular assays and animal studies.

"An understanding of nanotoxicity could also lead to the harnessing of their properties such as using nanoparticles that initiate cell death to be used for targeted chemotherapy approaches," said Nel, who also leads the Cellular Immunology Activation Laboratory in the Jonsson Cancer Center at UCLA.

Nel is a pioneer in researching and documenting the adverse health effects of air particles in the lung and cardiovascular system. He has studied the ability of particles to generate reactive oxygen radicals and oxidant injury, and the resulting effects on airway inflammation, asthma and atherosclerosis. His laboratory has become a leader in studying the adverse health effects of ultrafine (nano-size) particles in the body, including methods for predictive toxicity testing.

As nanomaterials are increasingly being used for commercial purposes the NanoSafety Lab’s goal is to help corporations deal with the safety and regulatory issues relating to the use of nanomaterials in their products. The testing approach is based on existing regimens and protocols in Nel’s laboratory as well as new techniques being developed by research at CNSI, including collaboration with leading scientists around the country.

Rachel Chammpeau | EurekAlert!
Further information:
http://www.cnsi.ucla.edu

More articles from Materials Sciences:

nachricht Researchers invent process to make sustainable rubber, plastics
25.04.2017 | University of Delaware

nachricht Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging
24.04.2017 | Pohang University of Science & Technology (POSTECH)

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

NASA's Fermi catches gamma-ray flashes from tropical storms

25.04.2017 | Physics and Astronomy

Researchers invent process to make sustainable rubber, plastics

25.04.2017 | Materials Sciences

Transfecting cells gently – the LZH presents a GNOME prototype at the Labvolution 2017

25.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>