Tamoxifen alone may adequately control breast cancer, avoiding side effects
Older women treated with tamoxifen after removal of early-stage breast cancer by lumpectomy may safely be able to avoid radiation therapy and its unpleasant side effects. In the Sept. 2 New England Journal of Medicine, investigators from several major cancer research groups report that adding radiation to post-surgical tamoxifen treatment of women age 70 or older does not improve survival, has minimal impact on the risk of local tumor recurrence and does not prevent the need for eventual mastectomy. “If a patient does not need to have radiation therapy, her quality of life can improve significantly,” says Kevin Hughes, MD, of the Massachusetts General Hospital (MGH) Cancer Center, who led the study. “By showing that radiation therapy has very little impact on outcome for these patients, we can help each woman and her physician decide on the right treatment.”
Many breast cancers depend on the hormone estrogen to grow. So tamoxifen, which blocks the interaction between estrogen and its receptor protein, is used to treatment tumors that have that protein on the surface of their cells. Most older breast cancer patients have receptor-positive tumors and receive tamoxifen, a medication that has few side effects.
Sue McGreevey | EurekAlert!
Spider silk key to new bone-fixing composite
20.04.2018 | University of Connecticut
Diamond-like carbon is formed differently to what was believed -- machine learning enables development of new model
19.04.2018 | Aalto University
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
Stable joint cartilage can be produced from adult stem cells originating from bone marrow. This is made possible by inducing specific molecular processes occurring during embryonic cartilage formation, as researchers from the University and University Hospital of Basel report in the scientific journal PNAS.
Certain mesenchymal stem/stromal cells from the bone marrow of adults are considered extremely promising for skeletal tissue regeneration. These adult stem...
In the fight against cancer, scientists are developing new drugs to hit tumor cells at so far unused weak points. Such a “sore spot” is the protein complex...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
20.04.2018 | Physics and Astronomy
20.04.2018 | Interdisciplinary Research
20.04.2018 | Physics and Astronomy