Ames Laboratory researchers studying self-assembling polymers
A group of bioinspired polymers are being studied by researchers at the Department of Energys Ames Laboratory to understand how they are able to form and react to stimuli similar to the way proteins, lipids and DNA react in nature. Unlocking how these soluble block polymers are able to self-assemble could potentially lead to a variety of uses such as controlled release systems for sustained and modulated delivery of drugs or gene therapies.
Ames Laboratory materials chemist Surya Mallapragada and her research team are focusing on pentablock polymers - polymers that form in strings of five chains. Each string is comprised of two cationic (positively charged) blocks, two hydrophilic (water loving) blocks, and one hydrophobic block. Because the hydrophobic block tries to avoid water, it forms the center of the string, with the hydrophilic next and the cationic blocks on the outside. In solution, these strings form in small clusters called micelles, again with the hydrophobic blocks at the center.
Surya Mallapragada | EurekAlert!
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