Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Shape-memory polymers designed for biomedical applications

07.01.2008
Researchers design shape-memory polymers for biomedical applications

Researchers at the Georgia Institute of Technology are developing unique polymers, which change shape upon heating, to open blocked arteries, probe neurons in the brain and engineer a tougher spine.

These so-called shape-memory polymers can be temporarily stretched or compressed into forms several times larger or smaller than their final shape. Then heat, light or the local chemical environment triggers a transformation into their permanent shape.

“My focus has been to optimize these polymers for many different biomedical applications. My lab studies how altering the chemistry and structure of the polymers affects their chemical, biological and mechanical properties,” said Ken Gall, a professor in the George W. Woodruff School of Mechanical Engineering and School of Materials Science and Engineering.

The mechanical properties of these polymers make them extremely attractive for many biomedical applications, according to Gall, who described his research in this area during two presentations at the Materials Research Society’s fall meeting in November.

Engineers are always searching for materials that display unconventional properties able to satisfy the severe requirements for implantation in the body. Particular attention must be paid to the biofunctionality, biostability and biocompatibility of these materials, which come into contact with tissue and body fluids.

With funding from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH), Gall proposed replacing metallic cardiovascular stents with plastic ones because polymers more closely resemble soft biological tissue. Plus, polymers can be designed to gradually dissolve in the body.

“Metal stents are frequently covered in plastic anyway, so we set out to remove the metal leaving just a polymer sheath,” explained Gall. “Also, polymers are more flexible and do not stress the artery walls like the metals.”

Gall’s research group has designed a shape-memory polymer stent that can be compressed and fed through a tiny hole in the body into a blocked artery, just like a conventional stent. Then, the warmth of the body triggers the polymer’s expansion into its permanent shape, resulting in natural deployment without auxiliary devices. This work was published in the journal Biomaterials earlier this year.

For another project, Gall and graduate student David Safranski have been investigating how altering a polymer’s chemistry changes its properties, such as stretchiness. This project was funded by MedShape Solutions, an Atlanta company that Gall co-founded to develop medical devices primarily for use in minimally invasive surgery.

“You can tailor the polymer to moderate its strength, stiffness, stretchiness and expansion rate,” noted Gall.

They found that by changing the chemistry of the polymer backbone to include special side groups, they could increase of the amount of strain the polymer could withstand before failing without sacrificing stiffness. This discovery enabled the creation of polymers that could stretch farther and also push harder during recovery.

Gall and graduate student Scott Kasprzak are exploring how these polymers might be used as a deployable neuronal probe, with funding from the National Institute of Neurological Disorders and Stroke of the NIH.

“We’re looking for smart materials that can be synthesized in the size range of 100 microns – similar to the size of a strand of hair – and then be inserted into brain tissue,” explained Gall. “This type of probe would need to slowly change shape inside the brain as to not disturb any surrounding tissue.”

Another project in Gall’s laboratory is examining the use of these polymers for the spine. Most spinal surgeries are currently not performed arthroscopically, so Gall sees benefits in using these shape-memory materials to enable minimally invasive spinal surgery.

With funding from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Gall and graduate student Kathryn Smith are developing shape-memory polymers for the spine that are tough – meaning they stretch far and support a lot of weight like native spinal disks.

“This would improve the deliverability and life of artificial disks currently used in the spine. Essentially, we’re just trying to engineer tougher synthetic polymers that can be easily delivered,” explained Gall, who is collaborating on this project with Barbara Boyan and Johnna Temenoff, both of the Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

In addition to exploring different biomedical applications for shape-memory polymers, Gall has also turned his attention to manufacturing them. Walter Voit, a graduate student in the Technological Innovation: Generating Economic Results (TI:GER) program, is investigating how to produce shape-memory polymers at a low cost. More specifically, Voit is examining different types of materials and processing methods that can be used to commercially produce quality polymers for lower cost medical applications.

Abby Vogel | EurekAlert!
Further information:
http://www.gatech.edu

More articles from Materials Sciences:

nachricht Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously
17.01.2017 | Sonderforschungsbereich 668

nachricht Manchester scientists tie the tightest knot ever achieved
13.01.2017 | University of Manchester

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

How gut bacteria can make us ill

18.01.2017 | Life Sciences

On track to heal leukaemia

18.01.2017 | Health and Medicine

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>