Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein glue shows potential for use with biomaterials

28.08.2014

A paper published in Science and Technology of Advanced Materials have shown that a synthetic protein called AGMA1 has the potential to promote the adhesion of brain cells in a laboratory setting. It is also cheaper and easier to produce on a large scale. This could help overcome a major challenge in nerve tissue engineering.

Researchers at the University of Milan in Italy have shown that a synthetic protein called AGMA1 has the potential to promote the adhesion of brain cells in a laboratory setting. This could prove helpful in improving cell adhesiveness to biomaterials.


Improving cell adhesion to biomaterials is crucial for the development of implanted neural prostheses such as cochlear implants. Copyright : Wikimedia

Isolating nerve cells from their original organism and culturing them in the laboratory has long been used as a method to study brain metabolism. It has been challenging, however, to provide brain cell cultures with the necessary “adhesion promoters” that facilitate cell attachment, spreading, growth and morphological development.

Improving cell adhesion to biomaterials is also a major challenge in nerve tissue engineering and is crucial for the development of implanted neural prostheses, such as cochlear implants, and biosensors, such as blood glucose biosensors.

Coating the surfaces of negatively charged cell membranes with positively charged synthetic proteins promotes nerve adhesion and extension in laboratory settings. Most synthetic proteins, however, are toxic to living cells and thus need to be washed off before cell suspensions are spread onto a new plate. They are also unsuitable for applications that are used inside a living organism.

Within the central nervous system, extracellular matrix substances such as collagen and laminin promote the regeneration, differentiation, adhesion and migration of nerve fibers.

A protein sequence found in collagen and laminin has been identified as the minimum sequence that can mediate the adhesion of many cell types, including nerve cells.

AGMA1 is a basic synthetic protein that is biocompatible, water soluble, positively charged, and has a protein sequence similar to that found in collagen and laminin. It is much less toxic to living cells than conventionally used synthetic proteins. AGMA1 is also much easier to prepare on a large scale using relatively low-cost materials. As a result it is much cheaper.

University of Milan scientists tested the potential of AGMA1 to promote the adhesion, proliferation, and differentiation of primary brain cells in the laboratory.

Different primary cell types from rat brain were cultured on AGMA1, and the results compared with those of cells cultured under the same conditions on conventional substrates using other commonly used synthetic proteins. All experimental results showed that the performance of AGMA1 in this respect was comparable to that of conventional substrates.

For further information contact:

Dr Paolo Ferruti
Department of Chemistry
University of Milan
Milan, ITALY
E-mail: paolo.ferruti@unimi.it
Phone: +39-02-5031-4128 

Associated links

Journal information

Sci. Technol. Adv. Mater. 15 (2014) 045007

Mikiko Tanifuji | Research SEA News
Further information:
http://www.nims.go.jp/eng/
http://www.researchsea.com

Further reports about: Protein adhesion biomaterials organism promote proteins sequence substrates synthetic toxic types

More articles from Materials Sciences:

nachricht Engineering phase changes in nanoparticle arrays
26.05.2015 | DOE/Brookhaven National Laboratory

nachricht Nanobionics Supercharge Photosynthesis
22.05.2015 | Department of Energy, Office of Science

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Advance in regenerative medicine

The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.

Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

Im Focus: First electrical car ferry in the world in operation in Norway now

  • Siemens delivers electric propulsion system and charging stations with lithium-ion batteries charged from hydro power
  • Ferry only uses 150 kilowatt hours (kWh) per route and reduces cost of fuel by 60 percent
  • Milestone on the road to operating emission-free ferries

The world's first electrical car and passenger ferry powered by batteries has entered service in Norway. The ferry only uses 150 kWh per route, which...

Im Focus: Into the ice – RV Polarstern opens the arctic season by setting course for Spitsbergen

On Tuesday, 19 May 2015 the research icebreaker Polarstern will leave its home port in Bremerhaven, setting a course for the Arctic. Led by Dr Ilka Peeken from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) a team of 53 researchers from 11 countries will investigate the effects of climate change in the Arctic, from the surface ice floes down to the seafloor.

RV Polarstern will enter the sea-ice zone north of Spitsbergen. Covering two shallow regions on their way to deeper waters, the scientists on board will focus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Researchers develop intelligent handheld robots

27.05.2015 | Power and Electrical Engineering

"Hidden" fragrance compound can cause contact allergy

27.05.2015 | Health and Medicine

Supernovas help 'clean' galaxies

27.05.2015 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>