Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein glue shows potential for use with biomaterials

28.08.2014

A paper published in Science and Technology of Advanced Materials have shown that a synthetic protein called AGMA1 has the potential to promote the adhesion of brain cells in a laboratory setting. It is also cheaper and easier to produce on a large scale. This could help overcome a major challenge in nerve tissue engineering.

Researchers at the University of Milan in Italy have shown that a synthetic protein called AGMA1 has the potential to promote the adhesion of brain cells in a laboratory setting. This could prove helpful in improving cell adhesiveness to biomaterials.


Improving cell adhesion to biomaterials is crucial for the development of implanted neural prostheses such as cochlear implants. Copyright : Wikimedia

Isolating nerve cells from their original organism and culturing them in the laboratory has long been used as a method to study brain metabolism. It has been challenging, however, to provide brain cell cultures with the necessary “adhesion promoters” that facilitate cell attachment, spreading, growth and morphological development.

Improving cell adhesion to biomaterials is also a major challenge in nerve tissue engineering and is crucial for the development of implanted neural prostheses, such as cochlear implants, and biosensors, such as blood glucose biosensors.

Coating the surfaces of negatively charged cell membranes with positively charged synthetic proteins promotes nerve adhesion and extension in laboratory settings. Most synthetic proteins, however, are toxic to living cells and thus need to be washed off before cell suspensions are spread onto a new plate. They are also unsuitable for applications that are used inside a living organism.

Within the central nervous system, extracellular matrix substances such as collagen and laminin promote the regeneration, differentiation, adhesion and migration of nerve fibers.

A protein sequence found in collagen and laminin has been identified as the minimum sequence that can mediate the adhesion of many cell types, including nerve cells.

AGMA1 is a basic synthetic protein that is biocompatible, water soluble, positively charged, and has a protein sequence similar to that found in collagen and laminin. It is much less toxic to living cells than conventionally used synthetic proteins. AGMA1 is also much easier to prepare on a large scale using relatively low-cost materials. As a result it is much cheaper.

University of Milan scientists tested the potential of AGMA1 to promote the adhesion, proliferation, and differentiation of primary brain cells in the laboratory.

Different primary cell types from rat brain were cultured on AGMA1, and the results compared with those of cells cultured under the same conditions on conventional substrates using other commonly used synthetic proteins. All experimental results showed that the performance of AGMA1 in this respect was comparable to that of conventional substrates.

For further information contact:

Dr Paolo Ferruti
Department of Chemistry
University of Milan
Milan, ITALY
E-mail: paolo.ferruti@unimi.it
Phone: +39-02-5031-4128 

Associated links

Journal information

Sci. Technol. Adv. Mater. 15 (2014) 045007

Mikiko Tanifuji | Research SEA News
Further information:
http://www.nims.go.jp/eng/
http://www.researchsea.com

Further reports about: Protein adhesion biomaterials organism promote proteins sequence substrates synthetic toxic types

More articles from Materials Sciences:

nachricht Wonder material? Novel nanotube structure strengthens thin films for flexible electronics
24.04.2017 | University of Illinois College of Engineering

nachricht Gelatine instead of forearm
19.04.2017 | Empa - Eidgenössische Materialprüfungs- und Forschungsanstalt

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Molecular libraries for organic light-emitting diodes

24.04.2017 | Life Sciences

Research sheds new light on forces that threaten sensitive coastlines

24.04.2017 | Earth Sciences

Making lightweight construction suitable for series production

24.04.2017 | Machine Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>