A research group at Uppsala University, Sweden has developed a new responsive coating for implants used in surgery to improve their integration into bone and to prevent rejection.
Neutron scattering experiments at the Institut Laue-Langevin (ILL) in Grenoble, France have shown how a protein that promotes bone growth binds to this surface and can be released in a controlled way.
Orthopaedic and dental implants must last for many years. Success for these surgical components depends on integration into adjacent bone tissue. Gels made by modifying hyaluronan, a large biological molecule, can be used to coat implants. A new paper in Advanced Engineering Materials shows that the coated titanium surfaces can bind protein molecules which promote bone formation. These can be released slowly once the surface comes in contact with a solution of calcium ions. This process would stimulate the growth of bone on the implant.
The gel layers, a few millionths of a millimetre thick, were characterised using neutron reflection at the ILL, a technique that provides a detailed picture of what happens at a surface.
In their new paper the research team showed that the protein, BMP-2, that encourages bone growth was bound to the gel. They also demonstrated that the layer of protein was stable in water but could be released slowly by adding solutions containing calcium, a process that was observed in real time using neutron reflection to track the amount of protein at the surface.
The research group has now launched trials of similar materials for metal implants in rabbits. These ongoing studies are made in collaboration with the Swedish Agricultural University in Uppsala and they provide a step towards transfer of the results to clinical applications.
'Interdisciplinary research and partnerships allow advanced analytical tools to be applied to important but difficult medical and scientific challenges. This exciting work comes from shared goals of chemists and physicists as well as the Centre for Neutron Scattering at Uppsala University and the laboratories in Grenoble', says Professor Adrian Rennie.
'We envisage that the materials will be used in medicine to modulate the healing process in bone', says Associate Professor Dmitri Ossipov. He continues, 'Neutrons are an ideal tool to understand the interactions of metal surfaces, polysaccharide biopolymers, and proteins thanks to a contrast matching technique that highlights only the protein components at the interface.'
'Neutron scattering techniques are increasingly relevant to optimise bio-materials and to study systems that relate to health. The importance of combining conventional laboratory studies with those at a large scale facility to give a complete picture of a process was proven once more. This work arose from a studentship funded by the Institut Laue-Langevin which makes us proud of our PhD programme.' says Dr Giovanna Fragneto from the Institut Laue-Langevin.
For more information, please contact Adrian Rennie, tel:+46 (0)70-4250914, +46 (0)18-471 3596, e-mail: Adrian.Rennie@physics.uu.se or Ida Berts, tel: +49-(0)89 2180 2439, e-mail: Ida.Berts@physik.uni-muenchen.de
Berts, D. Ossipov, G. Fragneto, A. Frisk, A.R. Rennie, 'Polymeric smart coating strategy for titanium implants', Advanced Engineering Materials (2014).
Adrian Rennie | EurekAlert!
An innovative high-performance material: biofibers made from green lacewing silk
20.01.2017 | Fraunhofer-Institut für Angewandte Polymerforschung IAP
Treated carbon pulls radioactive elements from water
20.01.2017 | Rice University
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences