Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New method makes culture of complex tissue possible in any lab

Scientists at the University of California, San Diego have developed a new method for making scaffolds for culturing tissue in three-dimensional arrangements that mimic those in the body.

This advance, published online in the journal Advanced Materials, allows the production of tissue culture scaffolds containing multiple structurally and chemically distinct layers using common laboratory reagents and materials.

According to the UC San Diego researchers, this process is more affordable and widely feasible than previous methods that required expensive equipment and expertise.

The new approach is remarkably simple: solutions of the components of each layer, including polymers, are mixed with varying concentrations of a common inert reagent to control density. The solutions are layered so that the difference in density segregates each solution, and then polymerized so that they form a gel. The structure of each layer can be altered by varying the concentration of polymers, and the discreteness of the transition between layers can be altered by allowing the solutions to diffuse.

Lead author Jerome Karpiak, graduate student in the UCSD Biomedical Sciences Program, said, "We're excited about the relevance of this method to tissue engineering. Since it offers such straightforward spatial control over structure and composition of stratified tissue scaffolds, including cell type and density, this technology could help the field move much faster." Tissues cultured in vitro to mimic those in the body can potentially provide an alternative to transplantation for injured or degenerated tissue.

"We believe this approach will vastly broaden the number of labs capable of culturing complex tissue," said Adah Almutairi, PhD, assistant professor at the UCSD Skaggs School of Pharmacy and Pharmaceutical Sciences, the Department of Nanoengineering and the Materials Science and Engineering Program at the UCSD Jacobs School of Engineering. "Because manipulation of structure and concentrations of signal molecules is much easier in this system than in intact organisms, it holds great potential to advance the study of development and disease." For example, this method may offer a novel approach to study how surrounding molecules affect the growth of axons in neurodevelopmental disorders.

Additional researchers included Yogesh Ner, PhD. Research was funded in part by the National Institutes of Health Director's New Innovator program and King Abdulaziz City of Science and Technology.

Debra Kain | EurekAlert!
Further information:

More articles from Materials Sciences:

nachricht How nanoscience will improve our health and lives in the coming years
27.10.2016 | University of California - Los Angeles

nachricht 3-D-printed structures shrink when heated
26.10.2016 | Massachusetts Institute of Technology

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel light sources made of 2D materials

Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.

So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...

Im Focus: Etching Microstructures with Lasers

Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.

This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Prototype device for measuring graphene-based electromagnetic radiation created

28.10.2016 | Power and Electrical Engineering

Gamma ray camera offers new view on ultra-high energy electrons in plasma

28.10.2016 | Physics and Astronomy

When fat cells change their colour

28.10.2016 | Life Sciences

More VideoLinks >>>