A research group at Materials Nanoarchitectonics (MANA), National Institute for Materials Science (NIMS), succeeded in developing porous particles (mesoporous particles) consisting solely of phospholipids, a biological component, that are suitable for use as a drug delivery system.
A research group led by MANA Scientist Kohsaku Kawakami, postdoctoral researcher Shaoling Zhang and MANA Principal Investigator Katsuhiko Ariga, at the International Center for Materials Nanoarchitectonics (MANA), NIMS (Sukekatsu Ushioda, President), succeeded in developing porous particles (mesoporous particles) consisting solely of phospholipids, a biological component, that are suitable for use as a drug delivery system.
Figure 1. External views of porous phospholipid particles (electron micrographs) (a, b) Particles created in organic (non-aqueous) solvent, (c, d) particles created in organic solvent in the presence of small amount of water. Only hydrogenated soybean lecithin was used to create them. The shape of the particles varies greatly depending on the presence/absence of water in the solvent.
Copyright : MANA, NIMS
This study had been published in the Journal of Physical Chemistry C on 16 March, 2015. (Shaoling Zhang, Kohsaku Kawakami, Lok Kumar Shrestha, Gladstone Christopher Jayakumar, Jonathan P. Hill, and Katsuhiko Ariga, article title: Totally phospholipidic mesoporous particles) J. Phys. Chem. C, 2015, 119 (13), pp 7255–7263, DOI: 10.1021/acs.jpcc.5b00159.
Mesoporous materials are a type of material capable of serving as a drug delivery system. In conventional studies, hard materials such as silica and carbon materials have been used for such purposes, posing safety concerns to patients. The mesoporous material developed in this study consists exclusively of biologically-derived materials and is therefore expected to be very safe for humans.
Acquisition of official approval is one of the hurdles in the development of materials for use as a drug delivery system. To develop a certified pharmaceutical product, it is necessary to demonstrate the safety of the additive to be used before investigating the safety of the product itself.
For this reason, pharmaceutical companies tend to avoid using new additives, which had been slowing the development of new drug carriers. However, the phospholipids examined in this study have already been used as emulsions and liposomes, and thus are not regarded as new additives. This fact is a great advantage of this material in view of commercialization.
This material comprises highly uniform mesoporous particles with diameters ranging between 5 and 20 μm, depending on their composition. It is a very lightweight material with a bulk density of about 0.02 g/cm3, from which an aerodynamic diameter of 1 to 3 μm is calculated. These are ideal features for this material to be used as a powder inhalation carrier.
Since this material consists of lipid bilayer membranes that are similar to biological membranes, it possesses the characteristics of both mesoporous particles and liposomes. For example, it can be used with both hydrophobic and hydrophilic drugs. Hydrophobic drugs can be embedded in a lipid bilayer membrane, and hydrophilic drugs can be inserted into hydrophilic regions between lipid bilayer membranes.
Furthermore, as it is also feasible for the material to hold drugs in its mesopores, the material is capable of carrying drugs with various physical properties. Since phospholipids can be easily modified, it is conceivable that various kinds of surface modifications can be applied to the material.
This material is suited for industrial production as it can be easily prepared through freeze-drying. And it is expected to be useful as a drug carrier assuming any administration route and as a cosmetic ingredient. The unique shape of the particles also may add value to the commercial product.
This study had been published in the Journal of Physical Chemistry C issued by the American Chemical Society. It was also presented at the MANA Symposium at the Tsukuba International Congress Center (presentation: 3:20 p.m. on March 12, titled “Bio-inspired nanoarchitectonics for early and patient-oriented medical treatment” by K. Kawakami).
Mikiko Tanifuji | ResearchSEA
Argon is not the 'dope' for metallic hydrogen
24.03.2017 | Carnegie Institution for Science
Researchers make flexible glass for tiny medical devices
24.03.2017 | Brigham Young University
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
24.03.2017 | Materials Sciences
24.03.2017 | Physics and Astronomy
24.03.2017 | Physics and Astronomy