Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Mapping Atherosclerotic Arteries: Combined Approach Developed


A new method allows calcified and constricted blood vessels to be visualized with micrometer precision, and can be used to design containers for targeted drug delivery. Within the project “NO-stress”, materials scientists from the Medical Faculty of the University of Basel combined cutting-edge-imaging techniques to visualize and quantify the constrictions caused by atherosclerosis.

Cardiovascular diseases, including atherosclerosis, are associated with plaque formation and the most prevalent cause of death worldwide. Unlike vessels and other soft tissues, the plaque formed provides strong contrast in X-rays, as known from bone. So far, it has therefore been difficult or even impossible to identify soft tissues in the direct neighborhood of calcifications using X-rays.

Conventional micro-tomography using intense X-rays allows for the visualization of plaque (white) and muscle tissue (black). Biomaterials Science Center, University of Basel

A team of researchers from laboratories in three European countries, led by Bert Müller (Biomaterials Science Center at University of Basel), has developed a protocol that is based on the combination of hard X-ray tomography and established histology methods, to visualize the vessels constricted by atherosclerosis.

The data about the morphology of the constricted vessels is used to simulate blood flow and determine related shear stresses. The shear stress is significantly enhanced at the constrictions and forms the basis for the development of specialized nano-containers for the targeted and local delivery of vasodilation drugs.

Differentiation between soft and hard tissues

The new method combines known approaches and is not only suitable for the three-dimensional characterization of atherosclerotic blood vessels but also for any other combination of strongly and weakly X-ray absorbing species including cartilage and bone. It takes advantage of conventional X-ray absorption and, in addition, of X-ray phase contrast measurements, which are for example accessible via grating interferometry. As the phase contrast is much less dependent on the atomic number of the constituents than the absorption contrast, the soft tissues in the vicinity of hard tissues become much more easily visualized.

In summary, the authors demonstrate that strongly calcified arteries are thoroughly characterized by the combination of the non-destructive tomography measurements in X-ray absorption and phase contrast modes, and established histology techniques. The project “NO-stress” is funded within the National Research Programme NRP 62 “Smart Materials” by the Swiss National Science Foundation.

Original citation
Margaret N Holme, Georg Schulz, Hans Deyhle, Timm Weitkamp, Felix Beckmann, Johannes A Lobrinus, Farhad Rikhtegar, Vartan Kurtcuoglu, Irene Zanette, Till Saxer, Bert Müller
Complementary X-ray tomography techniques for histology-validated three-dimensional imaging of soft and hard human tissues
Nature Protocols 9, 1401-1415 | doi:10.1038/nprot.2014.091

Further information
Prof. Bert Müller, Biomaterials Science Center at the University of Basel, Tel. +41 (0)61 265 96 60, E-Mail:

Weitere Informationen: - Full Version

Christoph Dieffenbacher | Universität Basel
Further information:

More articles from Materials Sciences:

nachricht From ancient fossils to future cars
21.10.2016 | University of California - Riverside

nachricht Study explains strength gap between graphene, carbon fiber
20.10.2016 | Rice University

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

New method increases energy density in lithium batteries

24.10.2016 | Power and Electrical Engineering

International team discovers novel Alzheimer's disease risk gene among Icelanders

24.10.2016 | Life Sciences

New bacteria groups, and stunning diversity, discovered underground

24.10.2016 | Life Sciences

More VideoLinks >>>