In order to regenerate, knee cartilage, paradoxically, needs to be placed under mechanical stress, as happens whenever we take a step and our knees take our weight. When stimulated in this way, the cartilage cells develop receptors that are sensitive to the growth factors produced by the organism.
It is also at this very moment that they would be most receptive to medication. Working on this basis, Dominique Pioletti and Harm-Anton Klok from EPF Lausanne have developed a smart material that only releases a substance when the material is mechanically loaded.Threshold effect
The researchers then wanted to verify that it was actually the heating process resulting from the repetition of the mechanical loading that caused the dye to be released. During an initial experiment, the material was subjected to cyclic mechanical loading but the heat produced was evacuated in order to prevent any local temperature increase in the material. “This test enabled us to exclude a sponge-type function, whereby the dye was only being released as a result of the pressure,” explains Dominique Pioletti. During a second experiment, the nanoparticles were removed. The matrix heated up as expected due to the cyclic mechanical loading but none of the dye was released. The researchers concluded that the three elements of the composite material were required for the system as a whole to function as intended.Long-term prospects
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A new tool for discovering nanoporous materials
23.05.2017 | Ecole Polytechnique Fédérale de Lausanne
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23.05.2017 | Heraeus Noblelight GmbH
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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23.05.2017 | Event News
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26.05.2017 | Life Sciences
26.05.2017 | Life Sciences
26.05.2017 | Physics and Astronomy