Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Improving the performance of titanium implants by bioactive composite coatings

07.10.2013
Researchers in Japan and China tested a novel urease fabrication process for coating titanium implants with bioactive CaP/gelatin composites. Published in Science and Technology of Advanced Materials, the research suggests that titanium implants coated with CaP and gelatin have great potential in clinical joint replacement or dental implants.

Titanium (Ti) and its alloys are the most popular materials used in orthopedic implants because of their good mechanical and chemical properties, biocompatibility, corrosion resistance and low allergenicity. One drawback, however, is that they cannot bond directly to living bone, but need to be coated with bioactive materials to improve their integration.


Figure 1. Masson’s trichrome surface staining of bone-implant interface after implantation for 4 weeks (A, C, E) and 8 weeks (B, D, F) (n = 3). A, B: pure Ti; C, D: CaP/ Ti; E, F: CaP/gel/Ti.

Calcium phosphate (CaP) and collagen are the main constituents of natural bone, and therefore gelatin – a denatured form of collagen – has excellent biodegradability and biocompatibility properties. Many organic-inorganic composites combine the advantages of each component, hence a composite of CaP and gelatin may be an effective coating for Ti implants.

In a study published in the journal Science and Technology of Advanced Materials, researchers in Japan and China tested a novel urease fabrication process for coating titanium implants with bioactive CaP/gelatin composites.

In the study, Wei-Qi Yan and colleagues implanted tiny 2 mm by 10 mm CaP/gel/Ti and CaP/Ti rods into the thigh bone of rabbits, while pure Ti rods served as controls. Four and eight weeks following the operation, the authors observed much more new bone on the surface of the composite CaP/gel/Ti rods than in the other two groups. What's more, the CaP/gel/Ti rods bonded to the surrounding bone directly, with no intervening soft tissue layer.

The authors concluded that the CaP/gel/Ti implants fabricated using their urease process not only enhanced the proliferation of stem cells and differentiation of bone cells, but also the bone bonding ability of the implants. This research suggests that titanium implants coated with CaP and gelatin have great potential in clinical joint replacement or dental implants.

For more information about this research, please contact:

National Institute for Materials Science, Tsukuba, Japan
Email: stam_office@nims.go.jp
Tel. +81-(0)29-859-2494

Journal information
[1] Zhong-Ming Huang et al, Promotion of osteogenic differentiation of stem cells and increase of bone-bonding ability in vivo using urease-treated titanium coated with calcium phosphate and gelatin, Sci. Technol. Adv. Mater. 14 (2013) 055001 (doi:10.1088/1468-6996/14/5/055001)

Mikiko Tanifuji | Research asia research news
Further information:
http://www.nims.go.jp
http://www.researchsea.com

More articles from Materials Sciences:

nachricht Scientist invents way to trigger artificial photosynthesis to clean air
26.04.2017 | University of Central Florida

nachricht Researchers invent process to make sustainable rubber, plastics
25.04.2017 | University of Delaware

All articles from Materials Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>