Titanium (Ti) and its alloys are the most popular materials used in orthopedic implants because of their good mechanical and chemical properties, biocompatibility, corrosion resistance and low allergenicity. One drawback, however, is that they cannot bond directly to living bone, but need to be coated with bioactive materials to improve their integration.
Figure 1. Masson’s trichrome surface staining of bone-implant interface after implantation for 4 weeks (A, C, E) and 8 weeks (B, D, F) (n = 3). A, B: pure Ti; C, D: CaP/ Ti; E, F: CaP/gel/Ti.
Calcium phosphate (CaP) and collagen are the main constituents of natural bone, and therefore gelatin – a denatured form of collagen – has excellent biodegradability and biocompatibility properties. Many organic-inorganic composites combine the advantages of each component, hence a composite of CaP and gelatin may be an effective coating for Ti implants.
In a study published in the journal Science and Technology of Advanced Materials, researchers in Japan and China tested a novel urease fabrication process for coating titanium implants with bioactive CaP/gelatin composites.
In the study, Wei-Qi Yan and colleagues implanted tiny 2 mm by 10 mm CaP/gel/Ti and CaP/Ti rods into the thigh bone of rabbits, while pure Ti rods served as controls. Four and eight weeks following the operation, the authors observed much more new bone on the surface of the composite CaP/gel/Ti rods than in the other two groups. What's more, the CaP/gel/Ti rods bonded to the surrounding bone directly, with no intervening soft tissue layer.
The authors concluded that the CaP/gel/Ti implants fabricated using their urease process not only enhanced the proliferation of stem cells and differentiation of bone cells, but also the bone bonding ability of the implants. This research suggests that titanium implants coated with CaP and gelatin have great potential in clinical joint replacement or dental implants.
For more information about this research, please contact:
From ancient fossils to future cars
21.10.2016 | University of California - Riverside
Study explains strength gap between graphene, carbon fiber
20.10.2016 | Rice University
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.
In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
24.10.2016 | Earth Sciences
24.10.2016 | Life Sciences
24.10.2016 | Physics and Astronomy