The device, called acoustic tweezers, is the first technology capable of touchlessly trapping and manipulating Caenorhabditis elegans (C. elegans), a one millimeter long roundworm that is an important model system for studying diseases and development in humans. Acoustic tweezers are also capable of precisely manipulating cellular-scale objects that are essential to many areas of fundamental biomedical research.
For many biological systems, acoustic tweezers will provide an excellent tool to mimic the conditions inside the body where cells are subject to waves of pressure and pulses of chemicals. According to Stephen Benkovic, Evan Pugh professor of chemistry and holder of the Eberly family chair in chemistry at Penn State, whose group contributed to the paper, “Acoustic tweezers will be used to position cells for interrogation by pulses of drug-like molecules to test as well as to exert mechanical forces on the cell wall. The cells will contain bio-chemical markers, so we can observe the effect of drug pulses or pressure on the cell’s biochemistry.”
Acoustic tweezers are very versatile, says Huang. “We can manipulate a single cell or we can manipulate tens of thousands of cells at the same time.” Currently, the size of objects that can be moved with acoustic tweezers ranges from micrometers to millimeters, although with higher frequencies, it should be possible to move objects in the nanoscale regime, they believe. Further work will include modifying the device to accommodate more fundamental biomedical studies with the Benkovic group. Ultimately, the patent pending technology could lead to compact, noninvasive, and inexpensive point-of-care applications, such as blood cell and cancer cell sorting and diagnostics. For now, the ability to trap and manipulate a living C. elegans for study is proof of their device’s potential utility.Contributing to the PNAS paper, “On-chip Manipulation of Single Microparticles, Cells, and Organisms Using Surface Acoustic Waves,” are Xiaoyun Ding, Sz-Chin Steven Lin, Brian Kirby, Hongjun Yue, Sixing Li, Jinjie Shi, Stephen J. Benkovic, and Tony Jun Huang. Funding for their research was provided by the National Science Foundation and the National Institutes of Health. To see a short video clip of cell manipulation, visit: http://www.mri.psu.edu/news/2012/acoustic_tweezers_capture_tiny_creatures/
Contacts: Tony Jun Huang at firstname.lastname@example.org, or 814 863-4209. Stephen J. Benkovic at email@example.com
Stephen J. Benkovic | Newswise Science News
Decoding cement's shape promises greener concrete
08.12.2016 | Rice University
Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D
08.12.2016 | DOE/Brookhaven National Laboratory
Physicists of the University of Würzburg have made an astonishing discovery in a specific type of topological insulators. The effect is due to the structure of the materials used. The researchers have now published their work in the journal Science.
Topological insulators are currently the hot topic in physics according to the newspaper Neue Zürcher Zeitung. Only a few weeks ago, their importance was...
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
09.12.2016 | Life Sciences
09.12.2016 | Ecology, The Environment and Conservation
09.12.2016 | Health and Medicine