The device, called acoustic tweezers, is the first technology capable of touchlessly trapping and manipulating Caenorhabditis elegans (C. elegans), a one millimeter long roundworm that is an important model system for studying diseases and development in humans. Acoustic tweezers are also capable of precisely manipulating cellular-scale objects that are essential to many areas of fundamental biomedical research.
For many biological systems, acoustic tweezers will provide an excellent tool to mimic the conditions inside the body where cells are subject to waves of pressure and pulses of chemicals. According to Stephen Benkovic, Evan Pugh professor of chemistry and holder of the Eberly family chair in chemistry at Penn State, whose group contributed to the paper, “Acoustic tweezers will be used to position cells for interrogation by pulses of drug-like molecules to test as well as to exert mechanical forces on the cell wall. The cells will contain bio-chemical markers, so we can observe the effect of drug pulses or pressure on the cell’s biochemistry.”
Acoustic tweezers are very versatile, says Huang. “We can manipulate a single cell or we can manipulate tens of thousands of cells at the same time.” Currently, the size of objects that can be moved with acoustic tweezers ranges from micrometers to millimeters, although with higher frequencies, it should be possible to move objects in the nanoscale regime, they believe. Further work will include modifying the device to accommodate more fundamental biomedical studies with the Benkovic group. Ultimately, the patent pending technology could lead to compact, noninvasive, and inexpensive point-of-care applications, such as blood cell and cancer cell sorting and diagnostics. For now, the ability to trap and manipulate a living C. elegans for study is proof of their device’s potential utility.Contributing to the PNAS paper, “On-chip Manipulation of Single Microparticles, Cells, and Organisms Using Surface Acoustic Waves,” are Xiaoyun Ding, Sz-Chin Steven Lin, Brian Kirby, Hongjun Yue, Sixing Li, Jinjie Shi, Stephen J. Benkovic, and Tony Jun Huang. Funding for their research was provided by the National Science Foundation and the National Institutes of Health. To see a short video clip of cell manipulation, visit: http://www.mri.psu.edu/news/2012/acoustic_tweezers_capture_tiny_creatures/
Contacts: Tony Jun Huang at firstname.lastname@example.org, or 814 863-4209. Stephen J. Benkovic at email@example.com
Stephen J. Benkovic | Newswise Science News
How nanoscience will improve our health and lives in the coming years
27.10.2016 | University of California - Los Angeles
3-D-printed structures shrink when heated
26.10.2016 | Massachusetts Institute of Technology
Physicists from the University of Würzburg have designed a light source that emits photon pairs. Two-photon sources are particularly well suited for tap-proof data encryption. The experiment's key ingredients: a semiconductor crystal and some sticky tape.
So-called monolayers are at the heart of the research activities. These "super materials" (as the prestigious science magazine "Nature" puts it) have been...
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
28.10.2016 | Power and Electrical Engineering
28.10.2016 | Physics and Astronomy
28.10.2016 | Life Sciences