Sticking power: new adhesive earns patent, could find place in space

The patent, “pH dependent adhesive peptides,” was issued to the Kansas State University Research Foundation, a nonprofit corporation responsible for managing technology transfer activities of K-State. The patent covers an adhesive made from peptides — a compound containing two or more amino acids that link together — that increases in strength as moisture is removed.

It was created by John Tomich, professor of biochemistry, and Xiuzhi “Susan” Sun, professor of grain science and industry. Assisting in the research was Takeo Iwamoto, an adjunct professor in biochemistry, and Xinchun Shen, a former postdoctoral researcher.

“The adhesive we ended up developing was one that formed nanoscale fibrils that become entangled, sort of like Velcro. It has all these little hooks that come together,” Tomich said. “It's a mechanical type of adhesion, though, not a chemical type like most commercial adhesives.”

Because of its unusual properties, applications will most likely be outside the commercial sector, Tomich said.

For example, unlike most adhesives that become brittle as moisture levels decrease, the K-State adhesive's bond only becomes stronger. Because of this, it could be useful in low-moisture environments like outer space, where astronauts could use it to reattach tiles to a space shuttle.

Conversely, its deterioration from water could also serve a purpose.

“It could be used as a timing device or as a moisture detection device,” Tomich said. “There could be a circuit or something that when the moisture got to a certain level, the adhesive would fail and break the circuit, sounding an alarm.”

The project began nearly a decade ago as Sun and a postdoctal researcher were studying the adhesive properties of soybean proteins. Needing an instrument to synthesize protein peptides, Sun contacted Tomich.

Serendipitously, Tomich's lab had developed a peptide some time ago that had cement-like properties. Tomich said he knew it was unusual but had set it aside to pursue other interests.

“When Dr. Sun and I resurrected this protein, we didn't use the whole thing — just a segment of it,” Tomich said. “We isolated a certain segment where the cells are highly attracted to each other and form these fibrils.”

Since their collaboration Tomich has taken the same sequence and changed the way it was designed. The new peptide, he said, will have an eye toward gene therapy.

Sun's lab is trying to optimize the sequence against adhesion, as well as study how peptide sequences influence adhesion properties and surface energy.

“I continue studying protein structures and functional properties in terms of adhesion — folding, aggregation, surface energy and gelling properties — so we can rationally design and develop biobased adhesives using plant proteins,” she said.

The research foundation is working with the National Institute for Strategic Technology Acquisition and Commercialization to license the patent.