Eosinophils as markers for asthma

In the study, the Icelandic company Decode Genetics together with Helmholtz Zentrum München and a number of other international research institutes performed a genome-wide association scan of more than 50,000 test persons. The researchers found several sequence variants associated with asthma.

“Two of the detected sequence variants are of significance for a biochemical pathway in the interleukin-1 cluster,” explained Dr. Matthias Wjst, who was one of the initiators of the study at the Institute of Inhalation Biology of Helmholtz Zentrum München. This finding confirms the results of a research group at Helmholtz Zentrum München from 2004, which showed that the IL-1 gene cluster is associated with asthma.

“We do not yet know what mechanisms underlie the effect of these sequence variants on the inflammatory cells,” Dr. Wjst said, “but these findings give us new starting points for a better understanding of the various hypotheses of allergic inflammation.”

Allergic and respiratory diseases are among the key research areas of Helmholtz Zentrum München, which is dedicated to disease research at the interface of genetics, lifestyle and environmental influences. The center’s research goal is to elucidate biological mechanisms to achieve a better understanding of the disease process and thus to develop therapies and prevention strategies. Neuherberg, January 8, 2009D. Gudbjartson et al.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. DOI 10.1038/ng.323

Media Contact

Michael van den Heuvel alfa

All latest news from the category: Studies and Analyses

innovations-report maintains a wealth of in-depth studies and analyses from a variety of subject areas including business and finance, medicine and pharmacology, ecology and the environment, energy, communications and media, transportation, work, family and leisure.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors