Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

For some women, preventive mastectomies pay off

06.09.2010
Study shows women with BRCA1 and BRCA2 genetic mutations significantly reduce their risk of breast and ovarian cancer with preventive surgeries

A long-term study of women with a genetic predisposition for breast or ovarian cancer showed that those who elected major preventive surgeries had a significantly reduced risk of those cancers.

The study, published Sept. 1 in the Journal of the American Medical Association, confirms the view of one of its researchers, Gail Tomlinson, M.D., Ph.D., interim director of the Greehey Children's Cancer Research Institute at The University of Texas Health Science Center at San Antonio.

Dr. Tomlinson said that for women with certain genetic mutations, risk-reducing mastectomies and removal of the fallopian tubes and ovaries can be worth it for the women and their families.

"We have believed this for 15 years," said Dr. Tomlinson, "but it's been so controversial — removing organs for cancer risk."

The idea can be jarring unless one considers that the women with the specific genetic mutations, BRCA1 and BRCA2, are seeing people in their family suffering from these cancers one after another, Dr. Tomlinson said. She noted that often these are women with young families and careers to worry about, and the worry about dying from cancer at an early age because of familial predisposition can be overwhelming.

"This is a compromise women are willing to accept and their husbands are willing to accept, because the whole family worries about whether the women are going to get breast cancer," Dr. Tomlinson said.

The study does not address quality of life issues after such radical surgery, and Dr. Tomlinson said that is a concern that must be weighed by the women and their families. But the relief of having that risk taken away is hard to measure.

The study also supports Dr. Tomlinson's effort to build a genetic program at the Cancer Therapy & Research Center at the UT Health Science Center, she said, noting that the first steps have been taken with the hiring of a genetic counselor to work with families at risk for cancer. It's a program that will have benefits across the generations, she said, helping people identify and deal with hereditary risks associated with more than just those two cancers.

In addition to breast and ovarian cancer, she said, "certain types of thyroid and kidney cancer run in families and early intervention can be lifesaving."

The study followed nearly 2,500 women at higher risk for breast or ovarian cancer because of two genetic mutations between 1974 and 2008 at 22 centers in Europe and North America.

In 247 women who chose risk-reducing mastectomies, no breast cancers were diagnosed, while one in 13 of the 1,372 who did not have the surgery were diagnosed with breast cancer. Women who had their ovaries and fallopian tubes removed had a lower risk of ovarian cancer, including those with prior breast cancer, and a lower risk of dying from either cancer.

The Cancer Therapy & Research Center (CTRC) at The University of Texas Health Science Center at San Antonio is one of the elite academic cancer centers in the country to be named a National Cancer Institute (NCI) Designated Cancer Center, and is one of only four in Texas. A leader in developing new drugs to treat cancer, the CTRC Institute for Drug Development (IDD) conducts one of the largest oncology Phase I clinical drug programs in the world, and participates in development of cancer drugs approved by the U.S. Food & Drug Administration. For more information, visit www.ctrc.net.

The Greehey Children's Cancer Research Institute

The Greehey Children's Cancer Research Institute is a unique and specialized cancer research center. The mission of the Greehey CCRI is to advance scientific knowledge relevant to childhood cancer and to accelerate the translation of knowledge into novel therapies. Through discovery, development and dissemination of scientific knowledge with relevancy to childhood cancer, the overarching aim of the Greehey CCRI is to impact the problem of cancer at all ages. For more information about the Greehey CCRI, visit ccri.uthscsa.edu.

The University of Texas Health Science Center at San Antonio, one of the country's leading health sciences universities, ranks in the top 3 percent of all institutions receiving National Institutes of Health (NIH) funding. Research and other sponsored program activity totaled a record $259 million in fiscal year 2009. The university's schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced approximately 26,000 graduates. The $739 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg. For more information on the many ways "We make lives better®," visit www.uthscsa.edu.

Elizabeth Allen | EurekAlert!
Further information:
http://www.uthscsa.edu

More articles from Studies and Analyses:

nachricht New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)

nachricht Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

Im Focus: Bacteria harness the lotus effect to protect themselves

Biofilms: Researchers find the causes of water-repelling properties

Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

Innovation 4.0: Shaping a humane fourth industrial revolution

17.05.2017 | Event News

 
Latest News

Supercomputing helps researchers understand Earth's interior

23.05.2017 | Earth Sciences

Study identifies RNA molecule that shields breast cancer stem cells from immune system

23.05.2017 | Life Sciences

Turmoil in sluggish electrons’ existence

23.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>