Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Women with MS More Likely to Have MS-Related Gene Than Men

06.01.2011
Women who have multiple sclerosis (MS) are more likely to have a gene associated with multiple sclerosis than men with the disease and it is this gene region where environment interacts with the genetics, according to a study published in the January 5, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Research has shown that the number of people diagnosed with MS has been rising, and the rate has been rising faster for women than for men.

The cause of MS is not known, but evidence suggests that it is triggered by environmental factors in people who are genetically susceptible to the disease. The main gene associated with MS is the human leukocyte antigen (HLA) class II gene, but most of the risk comes from interaction of both parental genes.

The study examined the HLA genes of 1,055 families with more than one person with MS in the family. The genes of 7,093 people were tested, which included 2,127 people with MS. The researchers looked at what the HLA genes were for the people with and without MS, whether people with MS inherited the susceptibility gene from their mother or their father, and what the relationship was between people in the same family with MS.

The researchers found that women with MS were 1.4 times more likely to have the HLA gene variant associated with MS than men with MS. A total of 919 women and 302 men had the HLA gene variant, compared to 626 women and 280 men who did not have the gene variant. This fits with other research by this research group showing that the environment interacts with this gene region to produce modification in risk associated with it. This appears to be an epigenetic mechanism.

“Our findings also show women with the HLA gene variant are more likely to transmit the gene variant to other women in their families than to men,” said study author George C. Ebers, MD, FMedSCi, of the University of Oxford in the United Kingdom and a member of the American Academy of Neurology.

The researchers also determined that second-degree relatives such as aunts and their nieces or nephews were more likely to inherit the gene variant than first-degree relatives such as siblings or parents and children.

“It appears that the less the genetic sharing between individuals, the higher the interaction is between female sex and inheritance of the HLA gene variant,” said Orhun Kantarci, MD, of the Mayo Clinic in Rochester, Minnesota, and a member of the American Academy of Neurology, who wrote an editorial on the study. “These findings pave the way for future studies of these genes, hopefully to advance our understanding of inheritance of complex diseases such as MS.”

The study was supported by the Multiple Sclerosis Society of Canada and the Multiple Sclerosis Society of the United Kingdom.

The American Academy of Neurology, an association of more than 22,500 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com

Angela M. Babb | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center

nachricht The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>