Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Women with MS More Likely to Have MS-Related Gene Than Men

06.01.2011
Women who have multiple sclerosis (MS) are more likely to have a gene associated with multiple sclerosis than men with the disease and it is this gene region where environment interacts with the genetics, according to a study published in the January 5, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

Research has shown that the number of people diagnosed with MS has been rising, and the rate has been rising faster for women than for men.

The cause of MS is not known, but evidence suggests that it is triggered by environmental factors in people who are genetically susceptible to the disease. The main gene associated with MS is the human leukocyte antigen (HLA) class II gene, but most of the risk comes from interaction of both parental genes.

The study examined the HLA genes of 1,055 families with more than one person with MS in the family. The genes of 7,093 people were tested, which included 2,127 people with MS. The researchers looked at what the HLA genes were for the people with and without MS, whether people with MS inherited the susceptibility gene from their mother or their father, and what the relationship was between people in the same family with MS.

The researchers found that women with MS were 1.4 times more likely to have the HLA gene variant associated with MS than men with MS. A total of 919 women and 302 men had the HLA gene variant, compared to 626 women and 280 men who did not have the gene variant. This fits with other research by this research group showing that the environment interacts with this gene region to produce modification in risk associated with it. This appears to be an epigenetic mechanism.

“Our findings also show women with the HLA gene variant are more likely to transmit the gene variant to other women in their families than to men,” said study author George C. Ebers, MD, FMedSCi, of the University of Oxford in the United Kingdom and a member of the American Academy of Neurology.

The researchers also determined that second-degree relatives such as aunts and their nieces or nephews were more likely to inherit the gene variant than first-degree relatives such as siblings or parents and children.

“It appears that the less the genetic sharing between individuals, the higher the interaction is between female sex and inheritance of the HLA gene variant,” said Orhun Kantarci, MD, of the Mayo Clinic in Rochester, Minnesota, and a member of the American Academy of Neurology, who wrote an editorial on the study. “These findings pave the way for future studies of these genes, hopefully to advance our understanding of inheritance of complex diseases such as MS.”

The study was supported by the Multiple Sclerosis Society of Canada and the Multiple Sclerosis Society of the United Kingdom.

The American Academy of Neurology, an association of more than 22,500 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

For more information about the American Academy of Neurology, visit http://www.aan.com

Angela M. Babb | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

New Study Will Help Find the Best Locations for Thermal Power Stations in Iceland

19.01.2017 | Earth Sciences

Not of Divided Mind

19.01.2017 | Life Sciences

Molecule flash mob

19.01.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>