Talk about surviving by a whisker. The most common type of stroke can be completely prevented in rats by stimulating a single whisker, according to a new study by UC Irvine researchers.
Strokes are the No. 3 cause of death in the U.S., after heart disease and cancer. About 795,000 Americans suffer them annually, according to the American Heart Association, and more than 137,000 die as a result.
So should we be tickling our own whiskers? And what about women, who are less likely to have facial hair? While it’s too soon to tell if the findings will translate to humans, researchers say it’s possible, and stubble is not required. We have sensitive body parts wired to the same area of the brain as rodents’ fine-tuned whiskers.
“It’s gender-neutral,” adds co-author Ron Frostig, professor of neurobiology & behavior.
He cautions that the research, funded by the National Institutes of Health, is a first step, albeit an important one. “This is just the beginning of the whole story,” he says, “with the potential for maybe doing things before a victim even reaches the emergency room.”
A stroke usually happens when a main artery bringing oxygen and nutrients to the brain either ruptures or is blocked by a clot, causing partial brain death. The key to preventing strokes in rats whose main cerebral artery has been obstructed, UCI researchers found, is to stimulate the blood-starved brain area.
The team discovered that mechanically stroking just one whisker for four minutes within the first two hours of the blockage caused the blood to quickly flow to other arteries – like cars exiting a gridlocked freeway to find detours.
But unlike freeway off-ramps, which can quickly clog, the alternate arteries expanded beyond their normal size, opening wide to allow critical blood flow to the brain. The technique was 100 percent effective in preventing strokes in rats with arterial obstruction.
UC San Diego neuroscientist David Kleinfeld, who has also studied brain structure and strokes, calls the results “unexpected and spectacular.” Random stimulation of the rat whisker also worked, but timing was critical – waiting three hours to do so led to major brain cell death.
Scientists have struggled for years to find ways of preventing strokes or minimizing their effects, which include slurred speech, paralysis and brain damage. One drug can help some patients but also often causes bleeding in the brain.
People believed to be suffering a stroke are currently told to lie still and stay calm in a quiet environment. Frostig says a good massage, listening to a song or otherwise stimulating the right nerve endings might work better.
Kleinfeld cautions that the rodent findings might not be relevant to humans. But with such clear evidence that strokes in rats were prevented, he says, “it would be criminal not to try” controlled human studies. That could be tricky, since it’s not possible to predict when someone will have a stroke.
The UCI team – which also includes graduate student Christopher Lay and researcher Cynthia Chen-Bee – would like to find physicians or emergency medical technicians willing to try the technique on patients with early stroke symptoms.
Signs of stroke include:Sudden numbness or weakness in face or limbs, especially on one side.
About the University of California, Irvine: Founded in 1965, UCI is a top-ranked university dedicated to research, scholarship and community service. Led by Chancellor Michael Drake since 2005, UCI is among the most dynamic campuses in the University of California system, with nearly 28,000 undergraduate and graduate students, 1,100 faculty and 9,000 staff. Orange County’s largest employer, UCI contributes an annual economic impact of $3.9 billion. For more UCI news, visit www.today.uci.edu.
News Radio: UCI maintains on campus an ISDN line for conducting interviews with its faculty and experts. Use of this line is available for a fee to radio news programs/stations that wish to interview UCI faculty and experts. Use of the ISDN line is subject to availability and approval by the university.
Janet Wilson | EurekAlert!
Drone vs. truck deliveries: Which create less carbon pollution?
31.05.2017 | University of Washington
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.
Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
26.06.2017 | Life Sciences
26.06.2017 | Physics and Astronomy
26.06.2017 | Information Technology