New studies identify brain changes in people with Alzheimer's disease. The results give researchers a greater understanding of the disease and may help at-risk individuals by improving early detection.
New animal research also shows a novel approach to Alzheimer's vaccine design that may avoid dangerous side effects. These new results were reported at Neuroscience 2010, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news on brain science and health.
About 5.3 million people have Alzheimer's disease, according to the Alzheimer's Association. With the aging baby boomer population, Alzheimer's will continue to affect more people worldwide. Better diagnostic techniques may help identify the disease at earlier, potentially more treatable stages.
Today's new findings show that:
People with Alzheimer's disease show structural changes in the caudate nucleus, a brain structure typically associated with movement disorders such as Parkinson's disease, suggesting that the disease produces broader damage in the brain than previously thought (Sarah Madsen, abstract 348.4, see attached summary).
People at risk for Alzheimer's disease exhibit a structural change in portions of the cerebral cortex, which is largely responsible for reasoning, memory and other "higher function" tasks. The findings may help identify those who would most benefit from early intervention (Sarah George, abstract 756.9, see attached summary).
A new vaccine, which was tested in mice, could protect against memory problems associated with Alzheimer's disease without potentially dangerous side effects. The vaccine targeted a non-human protein that may make it a safer alternative to previous vaccine approaches that caused inflammation in human clinical trials (Charles Glabe, PhD, abstract 725.6, see attached summary).
Too many small aggregates of a protein called tau in the brain can directly interfere with memory, according to new animal research. The findings are important because they suggest that tau may be a good target for developing therapies against Alzheimer's and related diseases (Ottavio Arancio, MD, PhD, abstract 527.8, see attached summary).
"Identifying those at risk for Alzheimer's and developing new treatments for nervous system disorders is a social imperative," said press conference moderator Sam Sisodia, PhD, of the University of Chicago, an expert on the cellular biology of proteins implicated in Alzheimer's disease. "These studies are evidence that we're making real progress to overcome this tragic epidemic."
This research was supported by national funding agencies, such as the National Institutes of Health, as well as private and philanthropic organizations.
Kat Snodgrass | EurekAlert!
Physics of bubbles could explain language patterns
25.07.2017 | University of Portsmouth
Obstructing the ‘inner eye’
07.07.2017 | Friedrich-Schiller-Universität Jena
Spectrally narrow x-ray pulses may be “sharpened” by purely mechanical means. This sounds surprisingly, but a team of theoretical and experimental physicists developed and realized such a method. It is based on fast motions, precisely synchronized with the pulses, of a target interacting with the x-ray light. Thereby, photons are redistributed within the x-ray pulse to the desired spectral region.
A team of theoretical physicists from the MPI for Nuclear Physics (MPIK) in Heidelberg has developed a novel method to intensify the spectrally broad x-ray...
Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.
Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
26.07.2017 | Event News
21.07.2017 | Event News
19.07.2017 | Event News
28.07.2017 | Health and Medicine
28.07.2017 | Power and Electrical Engineering
28.07.2017 | Life Sciences