Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Water method for unsedated colonoscopy; interval between prep and colonoscopy predicts prep quality

03.03.2009
GIE: Gastrointestinal Endoscopy special issue: Colonoscopy for colorectal neoplasia

In recognition of National Colorectal Cancer Awareness Month during March, GIE: Gastrointestinal Endoscopy has put out a special issue on colonoscopy for colorectal neoplasia. Studies of note regarding colonoscopy appear in both the monthly March issue and the special issue.

A study appearing in the March issue from researchers in California focuses on the impact of a novel water method on scheduled unsedated colonoscopy in U.S. veterans. Researchers in Texas looked at how the time interval between the completion of the last dose of bowel preparation and the start of colonoscopy predicts the quality of the bowel preparation in a study appearing in the special issue. GIE: Gastrointestinal Endoscopy is the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

Endoscopy is a procedure that uses an endoscope -- a thin, flexible tube with a light and a lens on the end to look into the esophagus, stomach, duodenum, small intestine, colon, or rectum, in order to diagnose or treat a condition. There are many types of endoscopy, including colonoscopy, sigmoidoscopy, gastroscopy, enteroscopy, and esophogogastroduodenoscopy (EGD). Colonoscopy is frequently used to screen for colorectal cancer, which most typically develops from polyps (growths in the colon).

March Issue: "Impact of a novel water method on scheduled unsedated colonoscopy in U.S. veterans"

During a colonoscopy, the colon must be distended (expanded) in order to pass the colonoscope through the full length of the colon to the cecum (the cul-de-sac lying below the terminal ileum forming the first part of the large intestine or colon ). The advancement of the scope into the cecum is termed cecal intubation and is mandatory for colonoscopy to be effective. Air is the usual medium to distend the bowel. However, air insertion can lengthen the colon (much like an accordion) and result in discomfort that may prevent cecal intubation, particularly in the unsedated patient.

The authors of this study used warm water, rather than air, to distend the colon based on their prior experience with this technique. They previously found that when water was infused into the colon instead of air during colonoscope insertion, approximately 50 percent of the colon exams could be completed without sedation. Based on this background information, researchers in California hypothesized that the novel water method would enhance cecal intubation and increase the proportion of patients willing to have another colonoscopy with no sedation.

An unsedated colonoscopy program was instituted in 2002 at the Veterans Affairs Sepulveda Ambulatory Care Center in California. From June 2005 to May 2006, the air method was used for colonoscopy. From June 2006 to October 2007 the water method was used. With the latter method, the air pump was disabled and "warm to touch" tap water in lieu of air was used. Sixty-two veterans were examined using the air method and 63 veterans were examined using the water method. The cecal intubation rate with the air method was 76 percent, while the water method was 97 percent. The proportion of patients who reported a willingness to repeat an unsedated colonoscopy was significantly higher with the water method at 90 percent compared with 69 percent for the air method.

This was a single center, observational, nonrandomized study in a small elderly male population. Despite these limitations, researchers note that the positive findings of enhanced cecal intubation rates, increased patient reported willingness to have another colonoscopy and improved cleanliness of the colon are sufficiently provocative to warrant calling for their confirmation by a randomized controlled trial with patients in the U.S. for unsedated colonoscopy.

Special Issue: "Duration of the interval between the completion of bowel preparation and the start of colonoscopy predicts bowel-preparation quality"

Recent studies suggest that colonoscopies done in the morning have better quality bowel preparations than those done in the afternoon; furthermore, preparations taken partially on the day of the exam are more effective than those taken entirely the day prior to the test. The right colon is particularly susceptible to inadequate cleansing. Effective bowel preparation is important for doctors to be able to clearly see the colon to look for abnormalities. Inadequate bowel preparation results in decreased rates of cecal intubation, increased rates of missing important lesions, increased patient discomfort and may result in cancellation or repetition of the colonoscopy.

Researchers at the Dallas Veteran's Affairs Medical Center noted an unacceptably high rate of inadequate bowel preparations and initiated a study to explore how to improve that rate. The primary aim of the study was to determine how the duration of the interval between the end of the preparation and the start of the colonoscopy affects preparation quality.

Between July and October 2007, 378 outpatients between the ages of 18 and 85 (96 percent men, mean age 62.2 years) were scheduled for elective colonoscopy. All patients were instructed to avoid iron supplements starting seven days before the colonoscopy. Two days before the procedure, patients were told to start a low-fiber diet. On the day before the procedure, patients were advised to drink only clear liquids and to avoid all solid foods. Study patients received one of three bowel preparations based on their ability to tolerate previous bowel preparations and on the presence of renal insufficiency and other comorbidities. The preparations used were polyethelene glycol electrolyte-based (PEG) and sodium phosphate (SP) solution (71 percent), oral PEG and magnesium citrate (23 percent), or SP alone (6 percent). The time of the final bowel preparation dose and the start time of the colonoscopy were recorded.

The physicians graded the overall quality of the preparation according to a scale developed by 10 experienced endoscopists at their center. The bowel preparation quality scale permitted a score of 4-unsatisfactory, 3-poor, 2-fair, 1-good, and 0-excellent. In the group as a whole, 52 percent had an excellent or good bowel preparation, 34 percent had a fair preparation, and 14 percent had a preparation rated poor or unsatisfactory. There was no difference between the three preparation varieties.

Patients with excellent or good bowel preparations (score 0-1) had a significantly shorter interval between the last preparation dose and the start of the colonoscopy (13.6 hours) when compared to patients with unsatisfactory to fair bowel preparations (14.35 hours). The researchers estimated that for every additional hour that the patient waits between the last preparation and the colonoscopy, the chance of having a good or excellent rating decreases by almost 10 percent.

In conclusion, researchers found that it is the duration of the interval between the completion of bowel preparation and the start of colonoscopy that is a major determinant of bowel preparation quality and a better determinant than the time of day when the colonoscopy is performed. Colonoscopy should begin a minimum of 14 hours following the last dose of bowel preparation to minimize the risk of an unsatisfactory preparation. In light of the findings, they adopted a split-dose bowel preparation regimen in their unit. In a split-dose regimen, the patient takes a portion of the bowel preparation solution the evening prior to the procedure with the second dose taken the day of the colonoscopy. The second dose minimizes the interval between preparation and colonoscopy, and this technique has been shown to result in superior bowel preparation by other investigators.

Anne Brownsey | EurekAlert!
Further information:
http://www.asge.org

More articles from Studies and Analyses:

nachricht Real-time feedback helps save energy and water
08.02.2017 | Otto-Friedrich-Universität Bamberg

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>