Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Better vision ahead for many diabetic retinopathy patients

28.04.2010
Diabetic retinopathy clinical research network study finds new treatment more effective

A nationwide, government-sponsored study finds that people with a common form of diabetic retinopathy can benefit from a medication first developed to combat another potentially blinding disease, age-related macular degeneration (AMD).

Treating diabetic macular edema (DME) with ranibizumab (Lucentis) eye injections, plus laser treatment if needed, appears to result in better vision than laser treatment alone, according to the Diabetic Retinopathy Clinical Research (DRCR) Network study published today in Ophthalmology online, the journal of the American Academy of Ophthalmology (Academy). DME is the main cause of vision loss in people with diabetes mellitus.

At the one year follow-up, nearly 50% of study patients who received the new combined treatment had substantial improvement in vision, compared with 28% who received laser treatment alone. Laser treatment has been the standard of care for DME for 25 years.

"The results appear to be applicable to most people who have DME in the center of the macula with some vision loss, whether the person has Type 1 or Type 2 diabetes, is old or young, or is a woman or a man," said Neil M. Bressler, MD, the Chair of the nationwide DRCR Network, and Chief of the Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine.

"This is a seminal study of which ophthalmology should be very proud," said George A. Williams, MD, an Academy board member and Ophthalmology Department Chair, Oakland University William Beaumont School of Medicine. "First and most importantly, it provides patients an improved therapy for diabetic macular edema. Second, the DRCR Network study is the first multi-center, randomized clinical trial to show how ranibizumab and the laser work together to improve treatment."

The DRCR Network investigators studied 854 eyes (691 participants) at 52 clinical centers across the United States, and compared four treatment modalities: ranibizumab plus prompt laser treatment, ranibizumab plus deferred laser treatment (provided at 24 weeks or later, if indicated), a coritcosteroid (triamcinolone) eye injection plus prompt laser treatment, or prompt laser treatment alone.

At the one year follow up patients who had received ranibizumab with prompt or deferred laser treatment had, on average, significantly better visual acuity than the group treated with laser alone. Also, significantly more patients in the ranibizumab-treated groups gained vision, and fewer suffered vision loss. In patients who entered the study after having cataract surgery and lens implants, results for corticosteroids plus laser treatment appeared comparable to the ranibizumab results, but intraocular pressure (IOP) increased in some corticosteroid-treated patients. Elevated IOP is undesirable because it can increase the risk of glaucoma. Negative outcomes were minimal in patients treated with ranibizumab. Results at two years were comparable to year one, but the researchers urge further study to confirm the longer-term safety and effects of ranibizumab for diabetic macular edema patients.

"In the brave new world of health care reform, the DRCR Network will serve as a model for future comparative effectiveness studies," Dr. Williams said.

The Academy will review the DRCR Network results and recommendations to determine whether, going forward, ranibizumab plus laser treatment should be a preferred treatment for most patients with diabetic macular edema with characteristics similar to those enrolled in this DRCR Network study.

Drs. Bressler and Williams emphasize that people with diabetes should ask their ophthalmologists (Eye M.D.s) if the new treatment approach might be appropriate for them. Although ranibizumab is an FDA-approved drug for AMD, it is not yet specifically approved for use with DME. Not every insurance company covers its use for DME at this time, since the definitive DRCR Network study results have just been published, although some insurance companies currently do cover this use based on previous smaller studies with briefer follow-up. Also, the DRCR Network study did not evaluate a very similar drug, bevacizumab (Avastin), so definitive confirmation of its potential effectiveness in DME is not yet available.

Eds: Full text of the study is available from the Academy's media relations department.

About the American Academy of Ophthalmology

The American Academy of Ophthalmology is the world's largest association of eye physicians and surgeons—Eye M.D.s—with more than 27,000 members worldwide. Eye health care is provided by the three "O's" – opticians, optometrists and ophthalmologists. It is the ophthalmologist, or Eye M.D., who can treat it all: eye diseases and injuries, and perform eye surgery. To find an Eye M.D. in your area, visit the Academy's Web site at www.aao.org.

Mary Wade | EurekAlert!
Further information:
http://www.aao.org

More articles from Studies and Analyses:

nachricht Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT

nachricht Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>