Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Van Andel Research Institute Finding is Potential Predictor of Deadly Cancer Common in Asia

15.06.2011
Researchers from the United States, Singapore, and China partner to fight head and neck cancer nasopharyngeal carcinoma

In a study recently published in Cancer Research, Van Andel Research Institute (VARI) researchers found a protein that could help predict the spread of the head and neck cancer nasopharyngeal carcinoma (NPC); this protein could also serve as part of a treatment strategy to stop the spread of the disease.

Though uncommon in the United States, NPC is one of the most common malignant tumors in southern China and Southeast Asia with incidence rates nearly 25 times that of most of the rest of the world. VARI researchers worked with scientists in Singapore, China, and the United States on the study.

“This study does not just report another molecular marker for metastasis of nasopharyngeal cancer, these investigators have revealed an important process related to this molecule,” said Wei Zhang, Ph.D., Professor at M.D. Anderson Cancer Center. “Characterization of this process will open diverse opportunities for effective inhibition of this novel target for cancer metastasis.”

NPC is the most common cancer originating in the nasopharynx area of the throat and has the highest metastasis rate among head and neck cancers. By the time patients are diagnosed, the disease has usually spread to lymph nodes or distant organs such as the liver.

Working together with physicians and scientists at Sun Yat-sen University Cancer Center in China, VARI researchers found that the protein serglycin is a marker of metastasis for NPC. Higher levels of serglycin correlated with an unfavorable prognosis and the increased likelihood that cancer would spread to other parts of the body. Additionally, when researchers blocked the secretion of serglycin, it reduced the cells capacity to invade and metastasize, which could mean it may have potential as a therapeutic target to stop the spread of NPC.

“Serglycin is clearly important to metastasis in NPC, but there are other factors as well,” said Chao-Nan Qian, M.D. Ph.D., Senior Research Scientist in the Laboratory of Cancer and Developmental Cell Biology at VARI. Qian also served as a medical expert for the “Healthy China 2020” healthcare reform plan. “Finding genes that cooperate with Serglycin that are also involved in metastasis could result in a comprehensive approach to treat NPC, and potentially help it from from spreading.”

Partners in the study included Sun Yat-sen University Cancer Center in China, National Cancer Center Singapore, the University of South China, Singapore General Hospital, and The Wistar Institute in Philadelphia.

About Van Andel Institute
Established by Jay and Betty Van Andel in 1996, Van Andel Institute (VAI) is an independent research and educational organization based in Grand Rapids, Mich., dedicated to preserving, enhancing and expanding the frontiers of medical science, and to achieving excellence in education by probing fundamental issues of education and the learning process. Van Andel Education Institute (VAEI) is dedicated to strengthening science education and preparing and motivating individuals to pursue science or science-related professions. Van Andel Research Institute (VARI), the research arm of VAI, is dedicated to probing the genetic, cellular and molecular origins of cancer, Parkinson’s and other diseases and working to translate those findings into effective therapies. This is accomplished through the work of over 200 researchers in 18 on-site laboratories and in collaborative partnerships that span the globe. VARI is affiliated with the Translational Genomics Research Institute, (TGen), of Phoenix, Arizona.

Joe Gavan | EurekAlert!
Further information:
http://www.vai.org

More articles from Studies and Analyses:

nachricht Win-win strategies for climate and food security
02.10.2017 | International Institute for Applied Systems Analysis (IIASA)

nachricht The personality factor: How to foster the sharing of research data
06.09.2017 | ZBW – Leibniz-Informationszentrum Wirtschaft

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Ocean atmosphere rife with microbes

17.10.2017 | Life Sciences

Neutrons observe vitamin B6-dependent enzyme activity useful for drug development

17.10.2017 | Life Sciences

NASA finds newly formed tropical storm lan over open waters

17.10.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>