CDH is a birth defect where there exists a severe malformation (hole) of the diaphragm and is a major cause of death in infants due to pulmonary hypoplasia, an incomplete development of the lungs.
Researchers led by Rodrigo Ruano, MD, PhD, of the Faculdade de Medicina da Universidade de Sao Paulo, in Sao Paulo, Brazil, conducted a randomized trial between May 2008 and July 2010 to compare the safety and efficacy of FETO for the treatment of severe isolated CDH.
Twenty patients were assigned randomly to undergo FETO and 21 patients were assigned to no prenatal intervention (control).
FETO was performed between 26 and 30 weeks' gestation following a well-established protocol under maternal epidural anesthesia.
Delivery occurred at 35.6+2.4 weeks in the FETO group and at 37.4+1.9 weeks in the control group.
In an intention-to-treat analysis, results found that 10 of the 20 (50.0%) infants in the FETO group and one infant out of 21 (4.8%) in the control group survived. The findings demonstrate that FETO improves the chance of surviving after birth from less than 5% without this treatment to about 50% after this treatment.
The FETO procedure appears to improve survival by enhancing pulmonary growth as a consequence of fetal tracheal occlusion.
"The present study allows the establishment of this treatment as standard care for severe forms of congenital diaphragmatic hernia," Ruano concludes.
Full citation: Ruano et al. A Randomized Controlled Trial of Fetal Endoscopic Tracheal Occlusion Versus Postnatal Management of Severe Isolated Congenital Diaphragmatic Hernia. Ultrasound in Obstetrics & Gynecology; 2011. DOI: 10.1002/uog.10142
About the Author: Rodrigo Ruano, MD, PhD, is affiliated with the Faculdade de Medicina da Universidade de Sao Paulo.
About the Journal
Ultrasound in Obstetrics and Gynecology is the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology (ISUOG), Ultrasound in Obstetrics & Gynecology (UOG) is an international, peer-reviewed journal. Published monthly, the journal includes original papers, case reports, reviews, Editorial and Opinion articles, and a letters column. UOG is covered by all the primary indexes including Index Medicus and Current Contents, and is read by Obstetricians, Gynecologists, Radiologists, Pediatricians, Sonographers, Midwives and Radiographers. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1469-0705.
Amy Molnar | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences