"These findings open up the possibility of developing a relatively simple urine test that could detect OSA in snoring children. This would alleviate the need for costly and inconvenient sleep studies in children who snore, only about 20 to 30 percent of whom actually have OSA," said lead author David Gozal, M.D., professor and chairman of the pediatrics department at the University of Chicago.
The study results are published in the December 15 issue of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
Dr. Gozal and researchers from University of Chicago and the University of Louisville studied 90 children who were referred to the sleep clinic to be evaluated for suspected sleep disordered breathing. They also recruited 30 healthy, non-snoring children from the community to serve as controls. The children all underwent standard overnight polysomnography and were categorized either as having OSA, habitual snoring or no sleep disordered breathing.
The children's first sample of urine was collected the morning after the sleep study. The researchers used a sophisticated electrophoresis technique to screen hundreds of proteins simultaneously and found that a number of the proteins were differently expressed in children with OSA compared to children with habitual snoring or healthy, non-snoring children.
"It was rather unexpected that the urine would provide us with the ability to identify OSA," said Dr. Gozal. "However, the field of biomarkers is one that is under marked expansion and this certainly opens the way for possible simple diagnostic screening methods in the future."
While it is estimated that one to three percent of all children up to the age of nine may suffer from OSA, many more (up to 12 percent) experience habitual snoring. Because OSA can lead to cognitive, behavioral, cardiovascular and metabolic consequences in children, differentiating it from habitual snoring is essential. The initial approach is surgical by removing the enlarged tonsils and adenoids, and some children may end up needing CPAP after their surgery.
"We wish to validate these findings in urine samples from many children from laboratories around the country and to develop a simple color-based test that can be done in the physician office or by the parents," said Dr. Gozal.
Keely Savoie | EurekAlert!
Rutgers-led innovation could spur faster, cheaper, nano-based manufacturing
14.02.2018 | Rutgers University
New study from the University of Halle: How climate change alters plant growth
12.01.2018 | Martin-Luther-Universität Halle-Wittenberg
Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
23.03.2018 | Event News
19.03.2018 | Event News
16.03.2018 | Event News
23.03.2018 | Materials Sciences
23.03.2018 | Agricultural and Forestry Science
23.03.2018 | Physics and Astronomy