Developing early strategies for treatment may be possible, says Derek Cooke, Queen's University adjunct professor and a co-author of the study.
"Most pediatricians adopt a 'wait and see' attitude for children with limb misalignment when they're growing," says Dr. Cooke. "If we can spot factors creating changes in alignment early in bone development, theoretically we could stop or slow down the progression of osteoarthritis."
The data was collected using x-ray images from more than 3,000 adults aged 50 to 79 who either had knee pain or risk factors for knee osteoarthritis as a part of the Multi Centre Osteoarthritis Study (MOST). Subjects were reassessed after a 30-month period and the researchers found that osteoarthritic changes in the knee were most significant in individuals with pronounced (more than 1 cm) leg length inequality, the shorter leg being most affected.
Leg length inequality is difficult to detect. A small leg length differential – 1 cm or less – can be corrected with a shoe insert, while a bigger one can be corrected with surgery. But because the condition often goes undiagnosed, many people don't realize they have a leg length differential until they're diagnosed with osteoarthritis.
Arthritis in the knees can cause pain, swelling and stiffness, and limit mobility. Osteoarthritis is very common, affecting 1 in 10 Canadians. The older a person gets, the greater the chance he or she has of developing the disease.
OAISYS Inc. undertook the image analysis work, collecting the limb length and angles measurements for the MOST project.
William F Harvey from Boston University, currently at Tufts Medical Center, was the lead author on the paper, which was recently published in the journal Annals of Internal Medicine. Queen's University was the only Canadian university involved in this international study.
Kristyn Wallace | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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26.05.2017 | Life Sciences
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