Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

“Treatments Waiting to be Discovered” Inside New Database

06.08.2014

Your genes are blueprints for proteins, and molecules called microRNA can help to determine how often these genetic blueprints are manufactured into proteins. Researchers often ask what microRNA regulates a gene related to disease. Or what gene is regulated by a microRNA found in sick patients?


50 million data points along with sophisticated data analysis tools now live at new database, multiMiR.

Image: Flickr/ElifAyiter cc license.

The answers to these questions could help doctors and researchers manipulate protein levels in the body that cause disease, especially cancer. A University of Colorado Cancer Center study recently published in the top-ranked journal Nucleic Acids Research (NAR) describes a database named multiMiR, the most comprehensive database collecting information about microRNAs and their targets.

“You can’t imagine the tangled web of data that describes the cause and effect relationships of microRNAs and genes. This multiMiR database will let researchers search efficiently through these relationships for pairings relevant to the diseases they study,” says Katerina Kechris, PhD, associate professor of Biostatistics and Informatics at the University of Colorado Denver, and one of the study’s senior authors.

... more about:
»Cancer »Database »Medicine »combination »diseases »drugs »genes

In addition to assisting researchers search for relationships between microRNAs and their genetic targets, the database includes drugs known to affect these microRNAs and also lists diseases associated with microRNAs.

“Right now, within this database, investigators can find clues to potential new treatments for various diseases including cancer,” says Dan Theodorescu, MD, PhD, professor of Surgery and Pharmacology at the CU School of Medicine, director of the University of Colorado Cancer Center and one of the study’s senior authors.

The project includes nearly 50 million records representing the combination of 14 previously existing microRNA data repositories. The multiMiR database also links to previous research results relevant to these microRNAs. multiMiR combines this functionality within the leading open-source statistical software, R, allowing for increased flexibility for analysis and accessibility by data analysts everywhere.

Basically, researchers can input names of microRNAs, genes, drugs, diseases or any combination thereof. Then the researcher can ask the database for validated or predicted genetic targets of microRNAs, or for validated/predicted microRNAs that regulate specific genes. Similar is true of diseases and drugs – informatics tools show which diseases are associated with microRNAs and which (if any) drugs have been linked to a specific miRNA queried.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA:gene interactions that influence bladder cancer.

“We need data and then we need clever ways to look at it otherwise we drown in the wealth of information,” Theodorescu says. “This new tool will allow us to ask new questions of more data with greater precision and get better, more insightful results that will ultimately help develop new approaches for patient treatment.”

This work supported in part by NIH grants 01CA075115, K01AA16922, R01AA021131, R01AA016957 and R24AA013162

Garth Sundem | Eurek Alert!
Further information:
http://www.coloradocancerblogs.org/treatments-waiting-discovered-inside-new-database/

Further reports about: Cancer Database Medicine combination diseases drugs genes

More articles from Studies and Analyses:

nachricht Conserving soil and water in dryland wheat region
25.11.2014 | Washington State University

nachricht Asymptomatic atherosclerosis linked to cognitive impairment
25.11.2014 | Radiological Society of North America

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

Regional economic cooperation in Central Asia

21.11.2014 | Event News

Educating the Ecucators

13.11.2014 | Event News

36th Annual IATUL Conference 2015: Call for papers and posters

12.11.2014 | Event News

 
Latest News

Ultra-short X-ray pulses explore the nano world

25.11.2014 | Physics and Astronomy

Virtual money: User’s identity can be revealed much easier than thought

25.11.2014 | Information Technology

Cost-effective manufacturing of large-volume components with combined SLM and casting method

25.11.2014 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>