Older veterans who have experienced a traumatic brain injury (TBI) are 60 percent more likely to later develop dementia than veterans without TBI, according to a study published in the June 25, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The study also found that veterans with a history of TBI developed dementia about two years earlier than those without TBI who had developed dementia.
“These findings suggest that a history of TBI contributes risk for dementia in later life in veterans. If we assume that this relationship is causal, it seems likely that the same increased risk probably occurs with TBI in the civilian population as well,” said study author Deborah E. Barnes, PhD, MPH, of the University of California, San Francisco and the San Francisco Veterans Affairs Medical Center and a member of the American Academy of Neurology.
The study involved 188,784 veterans with an average age of 68 at the start of the study. All were free of dementia at the start of the study and had at least one visit to a VA health care facility at the start of the study and again an average of seven years later.
A total of 1,229 of the veterans had a TBI diagnosis. During the follow-up period, 196 veterans with TBI, or 16 percent, developed dementia, compared to 18,255, or 10 percent of those without TBI. After adjusting for other factors that could affect the risk of dementia, such as diabetes, high blood pressure, depression and alcohol abuse, researchers determined that veterans with TBI were 60 percent more likely to develop dementia than those without TBI.
On average, veterans with TBI developed dementia two years earlier than those without TBI, or at age 78.5 compared to 80.7. Also, those who did not develop dementia died 2.3 years earlier if they had a TBI versus no TBI (77.0 years versus 79.3 years). The researchers also found that the risk of dementia was higher in veterans with TBI who also had depression, post-traumatic stress disorder or cerebrovascular disease than in those with either TBI or these other conditions alone.
“This study convincingly shows that mild trauma has a role in increasing the risk of dementia and sheds light on the more complex relationship between medical and psychiatric diseases with TBI in the development of the future risk of dementias. Neuroscientists must take a careful and comprehensive approach and avoid oversimplified claims of causality,” said Rodolfo Savica, MD, MSc, of the University of Utah School of Medicine in Salt Lake City, and a member of the American Academy of Neurology, who wrote an editorial accompanying the study.
The study was supported by the U.S. Department of Defense/NCIRE and the National Institutes of Health.
To learn more about traumatic brain injury and dementia, please visit www.aan.com/patients.
The American Academy of Neurology, an association of more than 28,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
Rachel L. Seroka
Manager, Media and Public Relations
American Academy of Neurology
201 Chicago Avenue
Minneapolis, MN 55415
Ph: 612-928-6129 Mobile: 612-807-6968 Fax: 612-454-2744
Rachel L. Seroka | American Academy of Neurology
High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg
Brain connectivity reveals hidden motives
04.03.2016 | Universität Zürich
Using an ultra fast-scanning atomic force microscope, a team of researchers from the University of Basel has filmed “living” nuclear pore complexes at work for the first time. Nuclear pores are molecular machines that control the traffic entering or exiting the cell nucleus. In their article published in Nature Nanotechnology, the researchers explain how the passage of unwanted molecules is prevented by rapidly moving molecular “tentacles” inside the pore.
Using high-speed AFM, Roderick Lim, Argovia Professor at the Biozentrum and the Swiss Nanoscience Institute of the University of Basel, has not only directly...
If a person pushes a broken-down car alone, there is a certain effect. If another person helps, the result is the sum of their efforts. If two micro-particles are pushing another microparticle, however, the resulting effect may not necessarily be the sum their efforts. A recent study published in Nature Communications, measured this odd effect that scientists call “many body.”
In the microscopic world, where the modern miniaturized machines at the new frontiers of technology operate, as long as we are in the presence of two...
Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.
Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.
In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...
Honeycomb structures as the basic building block for industrial applications presented using holo pyramid
Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...
27.04.2016 | Event News
15.04.2016 | Event News
12.04.2016 | Event News
04.05.2016 | Physics and Astronomy
04.05.2016 | Physics and Astronomy
04.05.2016 | Materials Sciences