The paper, "Plasma levels of sphingosine l-phosphate are strongly correlated with haemotocrit, but variably restored by red blood cell transfusions," appeared in a recent edition of the journal Clinical Science.
For many years, the traditional treatment for hospitalized patients in the United States who have developed anemia — whether associated with medical illness, surgical procedures or trauma — has been red blood cell transfusion, despite the absence of supporting data in many patient populations.
While still a life-saving measure in emergency situations such as acute bleeding, emerging evidence suggests that transfusions may, in fact, be associated with risk beyond commonly-held concerns of microbial transmission and acute reactions. Researchers are currently trying to understand the mechanism behind this observed deleterious effect of transfusion, which seems to correlate with the duration of storage of blood (blood for transfusion may currently be stored up to 42 days).
Red blood cells carry and deliver an important biologically active lipid mediator, sphingosine 1-phosphate (S1P), which is required for maintaining the integrity of blood vessels.
In the study, investigators confirmed that individuals with anemia have lower circulating levels of S1P. They found that transfusion to correct anemia does not always restore levels of S1P and the inability to restore S1P may be associated with the age of the transfused blood. Levels of S1P decrease during storage of red blood cells, which may explain why transfusion of older blood is less able to restore S1P levels.
These findings could help to explain some of the reasons that blood transfusions can have adverse consequences. Future efforts may focus on supplementing red blood cells with S1P in an attempt to improve outcomes in transfusion.
Study authors include lead author Samy Selim; Susan Smyth, chief of the Division of Cardiovascular Medicine and a core member of the Saha CVRC research faculty; Manjula Sunkara, Abdlghaffar K. Salous, Steve W. Leung, Alison Bailey, Andrew J. Morris, and Charles L. Campbell, all of the UK Division of Cardiovascular Medicine; Richard Charnigos of the UK College of Public Health; and Evgeny V. Berdyshev of the University of Illinois at Chicago.
Allison Elliott | EurekAlert!
New study: How does Europe become a leading player for software and IT services?
03.04.2017 | Fraunhofer-Institut für System- und Innovationsforschung (ISI)
Reusable carbon nanotubes could be the water filter of the future, says RIT study
30.03.2017 | Rochester Institute of Technology
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences