Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New Tool May Help Improve Organ Donation Rates

27.04.2010
A new tool may help neurologists predict which coma patients may be candidates for organ donation, according to a study published in the April 27, 2010, print issue of Neurology®, the medical journal of the American Academy of Neurology.

Organ donations must take place within 60 minutes of when the heart stops beating. Coma patients and other people with irreversible brain injuries are often potential organ donors because their other organs are usually healthy.

“Neurologists must often predict whether the patient will be a candidate for organ donation, but the existing tools are not designed for people with critical brain disease or they require the patient to be taken temporarily off ventilator support to conduct the test,” said study author Alan Yee, DO, of the Mayo Clinic in Rochester, Minnesota. “This new test is a significant improvement because it can be conducted before the patient is taken off breathing support and is designed for people with critical brain disease.”

For the study, Yee and his colleagues analyzed the information from all patients during a seven-year period from the neurologic intensive care unit at the Mayo Clinic whose life support was withdrawn. Those who were brain dead or who did not have support for breathing were not included in the study.

A total of 149 comatose people were included in the study. After the withdrawal of life support, the heart stopped beating within 60 minutes for 75 people.

The study identified four factors that make it more likely that a person with irreversible brain damage will be a candidate for organ donation. The four factors are: no corneal reflex, no cough reflex, no motor response or extensor motor response, and high scores on the oxygenation index.

For the corneal reflex, people blink when the cornea is touched with a small piece of cotton or dripping water solution. People who do not have a corneal reflex are more likely to be candidates. People who do not have a cough reflex also are more likely to be candidates. For the cough reflex test, a chemical irritant is placed near the patient to see if the cough reflex will expel the irritant.

Responses to painful stimulation can also be tested. People who have no motor movements in response to pain and people who have extensor movements on their own or in response to pain are also more likely to be candidates for organ donation. Extensor motor response is a reflex movement of straightening the arms and legs.

People who have a score of greater than 4.2 on the oxygenation index, which is a test of how well the lungs are functioning, are also more likely to be good candidates for organ donation.

The study found that people with all four factors were 93 percent more likely to die within 60 minutes of withdrawal of life support than people with none of the factors. People with one of the four factors were 65 percent to 76 percent more likely to die within 60 minutes.

“This research will need to be validated with further studies, but it would be a valuable tool that could help improve organ donation rates after cardiac death and also help optimize the allocation of medical resources,” said Yee.

Study co-author Eelco Wijdicks, MD, also with the Mayo Clinic, is an author of a guideline on brain death that will be issued by the American Academy of Neurology in June.

The American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as multiple sclerosis, restless legs syndrome, Alzheimer’s disease, narcolepsy and stroke.

For more information about the American Academy of Neurology, visit http://www.aan.com.

VIDEO: http://www.youtube.com/AANChannel
TEXT: http://www.aan.com/press
TWEETS: http://www.twitter.com/AANPublic

Rachel L. Seroka | American Academy of Neurology
Further information:
http://www.aan.com

More articles from Studies and Analyses:

nachricht Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden

nachricht WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

Im Focus: Photoexcited graphene puzzle solved

A boost for graphene-based light detectors

Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...

Im Focus: Water is not the same as water

Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.

From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Novel method for investigating pore geometry in rocks

18.06.2018 | Earth Sciences

Diamond watch components

18.06.2018 | Process Engineering

New type of photosynthesis discovered

18.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>