“This has been an area of debate because observational studies have shown a reduced risk of Alzheimer’s disease with hormone therapy use, while a randomized controlled trial showed an increased risk.
Our results suggest that there may be a critical window near menopause where hormone therapy may possibly be beneficial,” said study author Peter P. Zandi, PhD, with Johns Hopkins University in Baltimore. “On the other hand, if started later in life, hormone therapy could be associated with an increased risk of developing Alzheimer’s disease.”
For the study, researchers followed 1,768 women ages 65 and older for 11 years. The women provided a history of their hormone therapy use and the date at which menopause began. A total of 1,105 women had used hormone therapy, consisting of estrogen alone or in combination with a progestin. During the study, 176 women developed Alzheimer’s disease dementia, including 87 of the 1,105 women who had taken hormone therapy compared to 89 of the 663 others.
The study found that women who began hormone therapy within five years of menopause had a 30-percent lower risk of Alzheimer’s dementia than those who had not used hormone therapy. The risk was unchanged among other hormone users who had begun treatment more than five years after menopause, but a higher risk of dementia was observed among women who had started a combined therapy of estrogen and progestin when they were at least 65 years old.
“While this well-designed study supports the possibility that short-term hormone use may reduce the risk of Alzheimer’s disease, more research is needed before we can make new clinical recommendations for women and their use of hormone therapy,” said Victor Henderson, MD, MS, with Stanford University in Stanford, Calif., and a Fellow of the American Academy of Neurology, who wrote an accompanying editorial.
The study was supported by the National Institute on Aging.
To learn more about Alzheimer’s disease, visit http://www.aan.com/patients.
The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit http://www.aan.com
Rachel L. Seroka | American Academy of Neurology
Smart Data Transformation – Surfing the Big Wave
02.12.2016 | Fraunhofer-Institut für Angewandte Informationstechnik FIT
Climate change could outpace EPA Lake Champlain protections
18.11.2016 | University of Vermont
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy