Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Team explores the effects of exercise on ulcerative colitis

03.07.2013
A new study indicates that aerobic exercise can lessen – or worsen – the symptoms of inflammatory bowel diseases such as ulcerative colitis, depending on the circumstances under which the exercise is undertaken.

The researchers found that, in contrast to their sedentary peers, mice allowed to run freely on an exercise wheel for six weeks had fewer symptoms of colitis after exposure to a chemical agent that induces colitis symptoms in mice.

However, mice forced to run at a moderate pace on a treadmill a few times per week for six weeks had more colitis symptoms and higher mortality after exposure to the agent than sedentary mice, the researchers found.

These seemingly contradictory findings add to a growing body of research into the role of exercise and stress in reducing or increasing the severity of a host of inflammatory states, including those associated with Alzheimer’s disease and infection with the influenza virus.

“We are building a strong case to investigate how exercise affects gut immune function in humans and why exercise may beneficially affect disease activity in ulcerative colitis patients, as a few preliminary studies have indicated,” said University of Illinois graduate student Marc Cook, who led the research with U. of I. kinesiology and community health professor Jeffrey Woods. “Our exciting new data give us some potential causes of these benefits that need to be tested in people, which is our ultimate goal.”

The scientists, whose work is reported in the journal Brain, Behavior, and Immunity, also found that voluntary wheel running significantly reduced the expression of some pro-inflammatory genes in the colon in the mouse model of colitis, while forced treadmill running significantly increased expression of many of those same genes. Forced running on a treadmill by itself, but not voluntary wheel running, also increased expression of an antibacterial signaling protein, suggesting that forced exercise disrupted the microbial environment of the gut.

“There is evidence that prolonged, intense exercise can cause gastrointestinal disruption in competitive athletes. However, very little is known about regularly performed moderately intense exercise, especially in those with inflammatory bowel diseases,” Woods said. “From a public health perspective, this would be important information to gather.”

In humans, inflammatory bowel diseases “cause chronic morbidity that significantly reduces physical functioning and quality of life in afflicted patients,” the authors wrote. Although diseases of the gut, including colitis, appear to arise spontaneously, scientists know that environmental influences such as diet, genetic factors, infection and psychological stress play a role.

The microbial populations of the gut are also key contributors to gastrointestinal health, and disruptions can trigger chronic inflammatory responses, “instigating clinical symptoms, including colon ulcers, rectal bleeding, diarrhea, abdominal pain, fatigue, and an overall altered emotional well-being,” the authors wrote. Ulcerative colitis also “significantly increases the risk of developing colorectal cancer later in life.”

A number of factors may help explain the different physiological responses to voluntary and forced exercise in the mice, including altered gut populations of harmful versus beneficial bacteria and changes to the resident populations of specific immune cells in the gut, the researchers said.

Although more studies must be conducted to clarify the interplay of exercise and stress in maintaining or undermining the health of the gut, the research “supports a role for exercise in the adjunct treatment of ulcerative colitis in humans,” the authors wrote.

The American College of Sports Medicine and the National Institutes of Health supported this research.

Editor’s notes: To reach Jeffrey Woods, call 217-244-8815, email woods1@illinois.edu. To reach Marc Cook, email marccook@illinois.edu.

The paper, “Forced Treadmill Exercise Training Exacerbates Inflammation and Causes Mortality While Voluntary Wheel Training is Protective in a Mouse Model of Colitis,” is available online.

Diana Yates | University of Illinois
Further information:
http://www.illinois.edu

More articles from Studies and Analyses:

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>