African Americans have more severe complications from systemic sclerosis, also known as scleroderma, than Caucasians. Findings published today in, Arthritis & Rheumatism, a journal of the American College of Rheumatology (ACR), show that compared with Caucasians, African-American patients were more likely to have antibodies that increased frequency and severity of pulmonary fibrosis, which is associated with decreased survival.
According to the ACR there are 49,000 adult American diagnosed with systemic sclerosis—an autoimmune disease where collagen build-ups in the skin and organs, causing the skin to harden, joint pain, breathing issues, and digestive problems. Medical evidence has confirmed that African Americans have an increased incidence and worse prognosis with systemic sclerosis than Caucasians. Previous research has shown that genetic differences among the races contribute to differences in auto-antibodies, which influence how the disease affects patients.
To understand how auto-antibodies affect systemic sclerosis in African-American and Caucasian patients, a research team led by Dr. Virginia Steen from Georgetown University Medical Center in Washington, DC, analyzed data from the Pittsburgh Scleroderma Database. This database includes demographic, clinical, autoantibody, organ involvement and survival information for 203 African-American and 2945 Caucasian scleroderma patients seen at the University of Pittsburgh Medical Center between 1972 and 2007.
Findings show that African Americans had higher frequencies of certain scleroderma-specific autoantibodies compared to Caucasians: anti-U3-RNP (40% vs. 2%), U1-RNP (16% vs. 7%) and anti-topoisomerase (27% vs. 21%). Anti-topoisomerase auto-antibodies in scleroderma are associated with a higher incidence of pulmonary fibrosis (scarring of the lungs) and greater disease severity, and in this study, African-American patients with this antibody had more frequent and more severe fibrosis than the Caucasians with this antibody. Pulmonary fibrosis was also more severe in African American patients with anti-U1 RNP auto-antibodies compared to Caucasian patients with this antibody but a difference in survival between the races was not apparent. Researchers determined that the auto-antibody anti-U3 RNP was linked to more severe gastrointestinal involvement in African Americans compared to Caucasians.
Pulmonary disease is the most common cause of scleroderma related deaths, and African-American race was independently associated with pulmonary fibrosis and African Americans are at greater risk for severe lung disease, which the authors suggest may be due to genetics or environmental factors. "Our findings confirm that more serious complications affect African Americans with system sclerosis than Caucasians," concludes Dr. Steen. "For African-American systemic sclerosis patients with severe lung disease, more aggressive treatment early on could improve their outcome."
This study is published in Arthritis & Rheumatism. Media wishing to receive a PDF of this article may contact email@example.com
Full citation: "A Clinical and Serologic Comparison of African American and Caucasian Patients with Systemic Sclerosis." Virginia Steen, Robyn T. Domsic, Mary Lucas, Noreen Fertig, Thomas A. Medsger, Jr. Arthritis & Rheumatism; Published Online: May 10, 2012 (DOI: 10.1002/art.34482).
Author Contact: To arrange an interview with Dr. Steen please contact Karen Mallet with Georgetown University at firstname.lastname@example.org.
About the Journal:
Arthritis & Rheumatism is an official journal of the American College of Rheumatology (ACR) and the Association of Rheumatology Health Professionals (ARHP), a division of the College, and covers all aspects of inflammatory disease. The American College of Rheumatology (www.rheumatology.org) is the professional organization who share a dedication to healing, preventing disability, and curing the more than 100 types of arthritis and related disabling and sometimes fatal disorders of the joints, muscles, and bones. Members include practicing physicians, research scientists, nurses, physical and occupational therapists, psychologists, and social workers. The journal is published by Wiley-Blackwell on behalf of the ACR. For more information, please visit http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1529-0131.
Wiley-Blackwell is the international scientific, technical, medical, and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world's leading societies. Wiley-Blackwell publishes nearly 1,500 peer-reviewed journals and 1,500+ new books annually in print and online, as well as databases, major reference works and laboratory protocols. For more information, please visit www.wileyblackwell.com or our online platform, Wiley Online Library (wileyonlinelibrary.com), one of the world's most extensive multidisciplinary collections of online resources, covering life, health, social and physical sciences, and humanities.
Dawn Peters | EurekAlert!
The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung
A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
20.01.2017 | Awards Funding
20.01.2017 | Materials Sciences
20.01.2017 | Life Sciences