Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the results provide confidence in the efficacy of breast-conserving treatments even among patients with aggressive, early disease.
Lumpectomy combined with radiation is a good treatment choice for women with early breast cancer; however, over the past 10 years, a growing number of women have been choosing mastectomy even for very small cancers. In certain populations—such as women who are young and those living in urban areas with high socioeconomic status—this trend has been most pronounced due to the perception that outcomes may be better with mastectomy than with lumpectomy.
Shelley Hwang MD, MPH, of the Duke Cancer Institute, and her colleagues looked to see whether some populations of women do in fact have better outcomes after mastectomy compared with lumpectomy and radiation. The researchers obtained information regarding all women who were diagnosed in the state of California with stage I or II breast cancer between 1990 and 2004 and who were treated with either mastectomy or lumpectomy plus radiation. The investigators followed 112,154 cases through 2009, and they looked for patterns among different age groups and across different breast cancer types.
In the first three years after surgery, women who underwent mastectomy had a higher risk of dying from heart disease and other diseases than women who underwent lumpectomy, possibly indicating that the latter group was generally healthier, according to Dr. Hwang. Over the entire study period, women were more likely to survive breast cancer after undergoing lumpectomy plus radiation than mastectomy. This was true among all age groups and cancer types, with the biggest benefit seen in women over 50 years of age with hormone-sensitive breast cancer. These women had a 14 percent decreased risk of dying from breast cancer during the study compared with their counterparts who underwent mastectomy.
"The findings in this study should reassure women that among all age groups and tumor types, lumpectomy continues to be an excellent choice for women with small early breast cancers," said Dr. Hwang.
Amy Molnar | EurekAlert!
Amputees can learn to control a robotic arm with their minds
28.11.2017 | University of Chicago Medical Center
The importance of biodiversity in forests could increase due to climate change
17.11.2017 | Deutsches Zentrum für integrative Biodiversitätsforschung (iDiv) Halle-Jena-Leipzig
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
11.12.2017 | Physics and Astronomy
11.12.2017 | Earth Sciences
11.12.2017 | Information Technology