The study, reported in the May 20 issue of the Journal of Pediatric Surgery, looked retrospectively at 24 pediatric patients diagnosed with a rare and aggressive pediatric cancer known as desmoplastic small round cell tumor (DSRCT).
Patients who received the surgical procedure called hyperthermic intraperitoneal chemotherapy (HIPEC) or "heated chemotherapy," had an overall 3-year survival rate of 71 percent. For patients who received only standard treatment, 26 percent survived three years.
Andrea Hayes-Jordan, M.D., assistant professor at the MD Anderson Children's Cancer Hospital, is the first and only surgeon in the country to perform the adult procedure on children using heated chemotherapy.
"This study demonstrates that the surgical technique is safe and advantageous for patients who have multiple tumors in their abdomen," said Hayes-Jordan, first author of the paper. "In the past, these patients were told there was nothing else to be done, but now we can add months and often years to the lives of these young patients using this surgery."
Previous studies have shown the synergy created when chemotherapy is heated. With HIPEC, Hayes-Jordan will spend 10 to 12 hours removing, or debulking, the hundreds of tumors in a patient's abdominal cavity. Then she will run the chemotherapy, heated at 40 to 41 degrees Celsius (104 to 106 degrees Fahrenheit), throughout the cavity while the patient lies on a cooling blanket to keep the body's temperatures at a safe level. The chemotherapy helps to kill any microscopic tumor cells that are left behind after the debulking surgery. Within one to two months, patients are often fully recovered from surgery and back to their regular activities.
Patients ranging in age from 5 to 43 years were included in the study, but those receiving HIPEC ranged from 5 to 25 years old. Results indicated that younger patients had better outcomes from HIPEC than patients older than 18 years. Disease-free survival was also better for those who received HIPEC in addition to debulking surgery. At one year, disease-free survival was 14 percent for those who only received debulking surgery as compared to 53 percent who received HIPEC.
"We really are encouraged that this is going to help many children with abdominal tumors," said Hayes-Jordan. "We're sharing this technology with other centers so that they will also be able to help these children. In the years to follow, we hope to try different chemotherapies with the procedure to better the outcomes and decrease any toxicities."
DRSCT is a rare and aggressive soft tissue sarcoma that primarily presents as multiple tumors in the abdominal and pelvic area. The disease most often occurs in young Caucasian males, with less than 200 cases being reported worldwide since 1989. The overall survival rate for DSRCT is approximately 30 to 55 percent, which in part is due to the disease being resistant to chemotherapy and radiation often. Hayes-Jordan also attributes the poor outcomes to the tumor cells left behind after debulking surgery that spread in the abdomen and to other organs.
"Four years ago we had little hope to give to families facing this disease we know very little about," said Peter Anderson, M.D., Ph.D., professor of pediatrics and senior author on the study. "Using a multi-modality treatment that includes heated chemotherapy, we can see some of our patients experience milestones such as another birthday, a graduation or even parenthood that they may not have had otherwise."
Hayes-Jordan hopes that the data published from the study will encourage more centers to begin performing HIPEC on pediatric patients with abdominal tumors. She also plans to extend the study to include cancers that metastasize to the abdominal area.
Other collaborators on the study were co-first author, Holly Green, as well as Nancy Fitzgerald, M.D., and Lianchun Xiao from MD Anderson.
About MD Anderson
The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. M. D. Anderson is one of only 40 comprehensive cancer centers designated by the National Cancer Institute. For six of the past eight years, including 2009, M. D. Anderson has ranked No. 1 in cancer care in "America's Best Hospitals," a survey published annually in U.S. News & World Report.
About the MD Anderson Children's Cancer Hospital
The University of Texas MD Anderson Children's Cancer Hospital has been serving children, adolescents and young adults for more than 50 years. In addition to the groundbreaking research and quality of treatment available to pediatric patients, the Children's Cancer Hospital provides its patients with comprehensive programs that help the children lead more normal lives during and after treatment. For further information, visit the Children's Cancer Hospital website.
Sara Farris | EurekAlert!
Multi-year study finds 'hotspots' of ammonia over world's major agricultural areas
17.03.2017 | University of Maryland
Diabetes Drug May Improve Bone Fat-induced Defects of Fracture Healing
17.03.2017 | Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...
In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
20.03.2017 | Event News
14.03.2017 | Event News
07.03.2017 | Event News
23.03.2017 | Health and Medicine
23.03.2017 | Physics and Astronomy
22.03.2017 | Materials Sciences