Scientists prevented age-related changes in the hearts of mice and preserved heart function by suppressing a form of the PI3K gene, in a study reported in Circulation: Journal of the American Heart Association.
“The study provides evidence that delaying or preventing heart failure in humans may be possible,” said Tetsuo Shioi, M.D., Ph.D., senior author of the study and assistant professor of medicine at Kyoto University Graduate School of Medicine in Kyoto, Japan.
“Advanced age is a major risk factor for heart failure. One reason is that aging increases the chance of exposure to cardiovascular risk factors. However, natural changes due to aging may also compromise the cardiovascular system.”
According to the American Heart Association, 5.7 million Americans have heart failure, and nearly 10 out of every 1,000 people over age 65 suffer heart failure every year.
Shioi and his colleagues studied elderly mice genetically engineered to suppress the activity of one form of the PI3K gene, which is a part of the insulin/IGF-1signaling system that helps regulate the lifespan of cells.
A variation of PI3K, known as the p110á isoform, plays an important role in tissue aging. Suppressing the isoform’s activity in the roundworm C. elegans extends its life. And in fruit flies, suppression prevents the age-dependent decline of heart function.
The Japanese researchers compared aged mice with a functional p110á to aged mice with suppressed p110á and found that mice with the suppressed gene had:• improved cardiac function;
The researchers concluded that PI3K’s role in cardiac aging involved regulating other points further downstream in the insulin/IGF-1signaling pathway, which resulted in changes in how insulin acted in heart cells. The biological mechanism by which suppressing the gene’s activity improved the survival of the mice remains unclear.
“The heart failure epidemic in the United States and many other countries is due, in part, to our aging population,” said Mariell Jessup, M.D., an American Heart Association spokesperson and professor of medicine at the University of Pennsylvania School of Medicine in Philadelphia. “Aging humans experience a slow but gradual loss of heart cells and a host of other cellular and sub-cellular abnormalities which make the remaining cells contract less efficiently. Thus, this early work in a mouse model, clarifying the role of PI3K in cardiac aging, could ultimately allow scientists to understand if human hearts are similarly influenced.”
Co-authors are: Yasutaka Inuzuka, M.D.; Junji Okuda, M.D.; Tsuneaki Kawashima, M.D.; Takao Kato, M.D.; Shinichiro Niizuma, M.D.; Yodo Tamaki, M.D.; Yoshitaka Iwanaga, M.D., Ph.D.; Yuki Yoshida, M.D., Ph.D.; Rie Kosugi, M.D., Ph.D.; Kayo Watanabe-Maeda, M.D., Ph.D.; Yoji Machida, M.D., Ph.D.; Shingo Tsuji, Ph.D.; Hiroyuki Aburatani, M.D., Ph.D.; Tohru Izumi, M.D., Ph.D.; and Toru Kita, M.D., Ph.D.
Author disclosures and funding sources are in the study.
Statements and conclusions of study authors published in American Heart Association scientific journals are solely those of the study authors and do not necessarily reflect the association’s policy or position. The association makes no representation or guarantee as to their accuracy or reliability. The association receives funding primarily from individuals; foundations and corporations (including pharmaceutical, device manufacturers and other companies) also make donations and fund specific association programs and events. The association has strict policies to prevent these relationships from influencing the science content. Revenues from pharmaceutical and device corporations are available at www.americanheart.org/corporatefunding.
Antarctic Ice Sheet mass loss has increased
14.06.2018 | Technische Universität Dresden
WAKE-UP provides new treatment option for stroke patients | International study led by UKE
17.05.2018 | Universitätsklinikum Hamburg-Eppendorf
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
15.06.2018 | Materials Sciences
15.06.2018 | Ecology, The Environment and Conservation
15.06.2018 | Power and Electrical Engineering