Researchers at Baylor College of Medicine have identified a new approach to treating brittle bone disease, a congenital disorder that results in fragile bones that break easily.
The study, published in the current issue of the journal Nature Medicine, showed that excessive activity of an important signaling protein in the matrix of the bone called transforming growth factor beta is associated with the cause of the disease.
"There are many genetic causes of brittle bone disease in children and adults," said Dr. Brendan Lee, professor of molecular and human genetics at Baylor and a Howard Hughes Medical Institute investigator. "We have discovered many of them but clinicians still cannot easily distinguish the different forms."
Lee said the new study suggested that there may be common mechanisms that cause the decreased quality and quantity of bone in these different forms.
"This identified an important concept in bone disease that while many different genetic mutations can affect the proteins in the bone matrix (like collagen) they act in a common pathway to cause the bone disease – that is they affect how signaling proteins called transforming growth factor beta (TGF) are delivered to cells in the bone," said Lee. "We now have a deeper understanding for how genetic mutations that affect collagen and collagen processing enzymes cause weak bones."
Collagen is the most common protein in the human body, and the four most common types are found in different types of tissues including bone, cartilage, blood vessels, and kidney.
In animal studies, Lee and his colleagues showed that blockade of the TGF proteins using an antibody could restore the quantity of bone in mice with different forms of brittle bone disease.
"This treatment appears even more effective than other existing approaches," said Lee.
There are currently drugs in development to block this pathway in humans, so eventually the work can be translated into human studies, he said.
Existing approaches revolve around symptom management such as prevention of bone fractures, physical therapy and bone strengthening drugs, not necessarily medications to target the underlying cause of the disease, he said.
The study is novel because it shows a personalized approach to more effective treatment patients with these forms of brittle bone disease.
"We hope this approach will also be useful in more common forms of osteoporosis," said Lee.
Lee is also co-director of the Rolanette and Berdon Lawrence Bone Disease Program of Texas, a collaboration of Baylor, The University of Texas MD Anderson Cancer Foundation and the Center for Skeletal Medicine and Biology at Baylor, a member of the prestigious Institute of Medicine and founder and director of the Skeletal Dysplasia Clinic at Texas Children's Hospital.
Co-authors on the report include Ingo Grafe, Tao Yang, Stefanie Alexander, Erica Homan, Caressa Lietman, Ming Ming Jiang, Terry Bertin, Elda Munivez, Yuqing Chen, Brian Dawson, all of Baylor; Yoshihiro Ishikawa and Hans Peter Bächinger of Oregon Health and Science University in Portland, Mary Ann Weis and David Eyre of the University of Washington in Seattle; T Kuber Sampath of the Genzyme Research Center in Massachusetts and Catherine Ambrose of the University of Texas Health Science Center at Houston.
Funding for this work was provided by the German Research Foundation/Deutsche Forschungsgemeinschaft, the Osteogenesis Imperfecta Foundation, Shriners Hospitals for Children, the Howard Hughes Medical Institute, and the National Institutes of Health.
Glenna Picton | Eurek Alert!
Study suggests new way of preventing diabetes-associated blindness
26.05.2015 | Johns Hopkins Medicine
Memories Influence Choice of Food
22.05.2015 | Universität Basel
The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.
Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...
Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.
Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...
Development and implementation of an advanced automobile parking navigation platform for parking services
To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...
The world's first electrical car and passenger ferry powered by batteries has entered service in Norway. The ferry only uses 150 kWh per route, which...
On Tuesday, 19 May 2015 the research icebreaker Polarstern will leave its home port in Bremerhaven, setting a course for the Arctic. Led by Dr Ilka Peeken from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) a team of 53 researchers from 11 countries will investigate the effects of climate change in the Arctic, from the surface ice floes down to the seafloor.
RV Polarstern will enter the sea-ice zone north of Spitsbergen. Covering two shallow regions on their way to deeper waters, the scientists on board will focus...
20.05.2015 | Event News
18.05.2015 | Event News
12.05.2015 | Event News
27.05.2015 | Power and Electrical Engineering
27.05.2015 | Health and Medicine
27.05.2015 | Physics and Astronomy