Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Study Suggests New Treatment Target for Deadly Brain Tumors

A study by UT Southwestern Medical Center researchers published online today in Nature reveals new insight into why the most common, deadly kind of brain tumor in adults recurs and identifies a potential target for future therapies.

Glioblastoma multiforme (GBM) currently is considered incurable. Despite responding to initial therapy, the cancer almost always returns. GBM is a fast-growing, malignant brain tumor that occurred in 15 percent of the estimated 22,000 Americans diagnosed with brain and nervous system tumors in 2010. The median survival rate is about 15 months, according to the National Cancer Institute.

“We identified a subset of brain tumor cells that are slower growing or remain at rest, and appear to be the source of cancer recurrence after standard therapy in which the drug temozolomide is given to stop the tumor’s growth,” said Dr. Luis Parada, chairman of developmental biology and director of the Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration. “Current therapy targets fast-growing tumor cells but not those responsible for new tumors. To the best of our knowledge, this is the first identification of a cancer stem-like cell in a spontaneously forming tumor inside a mammal.”

Using a genetically engineered mouse model of GBM, the researchers found that the resting tumor cells act more like stem cells – the non-cancerous cells the body uses to repair and replenish itself – which exist in a resting state until needed, he explained.

The existence of cancer stem cells in solid tumors remains controversial, Dr. Parada said, with some scientists in the field taking the concept for granted and others rejecting it outright. In addition, the definition of a cancer stem cell is a moving target, hence the use of the term stem-like cell in this study, he said.

“We are trying to better understand these cells. The important point is that we now are faced with technical obstacles, not conceptual ones,” said Dr. Parada.

Other UT Southwestern researchers involved include lead author and former postdoctoral student of developmental biology Dr. Jian Chen, who is now a senior scientist at OriGene Technologies in Wuxi, China; Yanjiao Li, a research associate of developmental biology; Dr. Tzong-Schiue Yu, a former graduate student of developmental biology and pediatrics; Dr. Renée M. McKay, assistant professor of developmental biology; Dr. Dennis K. Burns, professor of pathology; and Dr. Steven G. Kernie, a former associate professor of pediatrics and developmental biology. Drs. Kernie and Yu are now at Columbia University Medical Center.

The study was supported by grants from the National Institutes of Health, the Cancer Prevention and Research Institute of Texas, the Goldhirsh Foundation, and the James S. McDonnell Foundation.

This news release is available on our World Wide Web home page at
To automatically receive news releases from UT Southwestern via email,
subscribe at

Deborah Wormser | Newswise Science News
Further information:

More articles from Studies and Analyses:

nachricht Diagnoses: When Are Several Opinions Better Than One?
19.07.2016 | Max-Planck-Institut für Bildungsforschung

nachricht High in calories and low in nutrients when adolescents share pictures of food online
07.04.2016 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Inflammation Triggers Unsustainable Immune Response to Chronic Viral Infection

24.10.2016 | Health and Medicine

Microbe hunters discover long-sought-after iron-munching microbe

24.10.2016 | Life Sciences

Seeking balanced networks: how neurons adjust their proteins during homeostatic scaling.

24.10.2016 | Life Sciences

More VideoLinks >>>