Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study shows pine bark naturally improves kidney function in patients with metabolic syndrome

02.03.2011
Research reveals Pycnogenol demonstrates kidney protective benefits and lowers elevated blood pressure and blood sugar

HOBOKEN, NJ – The American Heart Association estimates 35 percent of adults in the U.S. suffer from metabolic syndrome, a group of risk factors characterized by obesity and the simultaneous presence of heart disease risk factors with high blood pressure, blood sugar and lipids.

In patients with metabolic syndrome, high blood pressure and blood glucose gradually impair kidney function, which in turn affects the organ's ability to filter waste from the body. A study published in the June 2010 issue of Panminerva Medica reveals Pycnogenol® (pic-noj-en-all), an antioxidant plant extract from the bark of the French maritime pine tree, demonstrates kidney health benefits in metabolic syndrome patients, with effective blood pressure control, reduced blood sugar, and further noticed lowered Body Mass Index (BMI) due to weight loss.

"Kidney damage is a common problem for people with metabolic syndrome due to the large number of cardiovascular rick factors involved. Similar to hypertension, there are no warning signs for suffering kidneys. Poor kidney function may further increase blood pressure, which in turn deteriorates the situation of the kidneys in a vicious circle" said Dr. Peter Rohdewald, a lead researcher of the study. "The results of this study demonstrate Pycnogenol®'s ability not only to control hypertension, but also to restore kidney function in those impacted by metabolic syndrome. Surprisingly, people taking Pycnogenol® not only demonstrated lower blood glucose levels, but also significant weight loss during the six months, yielding optimistic results for managing this condition."

The controlled study carried out at the Nephrology Unit at the L'Aquila Hospital in Italy investigated 58 hypertensive patients who presented all of the criteria for diagnosis of metabolic syndrome, as defined by the World Health Organization: hypertension, high blood lipids, high fasting blood glucose and obesity. Furthermore, all patients showed early signs of kidney problems as judged by elevated amounts of proteins (albumin) present in their urine.

Patients were divided into two groups and instructed to follow a healthier lifestyle with dietary improvements, moderate exercise and effective management of health risk factors. Both groups were treated with anti-hypertensive medication Ramipril, taking a standard dosage of 5 mg twice a day, with one group of 31 patients taking Pycnogenol® in addition to the medication.

In the group taking Pycnogenol®, 50 mg Pycnogenol® tablets were taken three times a day at approximately 8 a.m., 4 p.m. and 10 p.m., a total dosage of 150 mg of Pycnogenol® per day. Urine was collected during a 24 hour period for quantification of the protein albumin in the urine at baseline and again after six months of treatment. Fasting blood was drawn for standard blood analysis. Systolic and diastolic blood pressure and heart rate were monitored in the morning.

The study also shows Pycnogenol® is effective for improving blood pressure in patients with metabolic syndrome. The study found that taking Pycnogenol® as an adjunct to Ramipril significantly further lowered systolic and diastolic blood pressure as compared to the group taking Ramipril alone. While average blood pressure in the Ramipril group was lowered to borderline-high 128.2/90.2 mmHg, the values in the group taking Pycnogenol® with Ramipril reached essentially normal values (122.2/85.3 mmHg) after six months of treatment.

Kidney function improved in both groups as judged by a significant reduction of protein detected in collected urine. With Ramipril alone, urinary protein decreased by 22 percent and with the addition of Pycnogenol® it decreased by 52.7 percent. Further, the group taking Pycnogenol® had a lowered fasting blood glucose level, which was reduced from high average value 135.6 mg/dL at baseline to reach essentially healthy reference value 102.3 mg/dL after six months of treatment. Pycnogenol® also led to a remarkable improvement of blood flow velocity of the kidney arteries. Blood flow velocity in the kidneys significantly increased with Ramipril from systolic 17.2 to 23.8 cm/sec and diastolic 4.2 to 2.0 cm/sec. The addition of Pycnogenol® was more effective, improving blood flow from systolic 18.2 to 27.2 and diastolic 4.1 to 9.8 cm/sec.

Only the group taking Pycnogenol® was found to have significantly lost weight after six months as compared to baseline, from average BMI 26.5 to 25.0.

"The number of people affected by metabolic syndrome is ever increasing and kidney disease is a growing concern. Pycnogenol® cannot compensate for an unhealthy lifestyle, but certainly offers some urgently needed help. Our study suggests that essentially all major characteristics of metabolic syndrome are improved with Pycnogenol as part of a healthier lifestyle." said Dr. Rohdewald.

This preliminary evaluation shows Pycnogenol® to offer a natural solution for individuals with metabolic syndrome, particularly for kidney protection. Previous studies have shown Pycnogenol® as a supplement to anti-hypertensive medication further improves kidney flow and kidney function. Pycnogenol® has also been shown in several studies to lower blood glucose in diabetic patients.

About Pycnogenol®

Pycnogenol® is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and organic acids, which offer extensive natural health benefits. The extract has been widely studied for the past 40 years and has more than 280 published studies and review articles ensuring safety and efficacy as an ingredient. Today, Pycnogenol® is available in more than 700 dietary supplements, multi-vitamins and health products worldwide. For more information, visit www.pycnogenol.com.

About Natural Health Science, Inc.

Natural Health Science Inc. (NHS), based in Hoboken, New Jersey, is the North American distributor for Pycnogenol® (pic-noj-en-all) brand French maritime pine bark extract on behalf of Horphag Research. Pycnogenol® is a registered trademark of Horphag Research Ltd., Guernsey, and its applications are protected by U.S. patents #5,720,956 / #6,372,266 and other international patents. Horphag Research Ltd. Is the recipient of the 2008 Frost & Sullivan North American Health Ingredients Excellence in Research Award. NHS has the exclusive rights to market and sell Pycnogenol® in North America and benefits from more than 40 years of scientific research assuring the safety and efficacy of Pycnogenol® as a dietary supplement. For more information about Pycnogenol® visit our Web site at www.pycnogenol.com.

Katherine Davis | EurekAlert!
Further information:
http://www.mww.com
http://www.pycnogenol.com

More articles from Studies and Analyses:

nachricht The Great Unknown: Risk-Taking Behavior in Adolescents
19.01.2017 | Max-Planck-Institut für Bildungsforschung

nachricht A sudden drop in outdoor temperature increases the risk of respiratory infections
11.01.2017 | University of Gothenburg

All articles from Studies and Analyses >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>